Development of Pain-producing Substance in Human Plasma


WE have previously reported1–3 that inflammatory exudates and fresh plasma produce: (i) pain when applied to the exposed base of a cantharidin blister in man, and (ii) contraction of the isolated rat uterus. Since we find these two actions to run in parallel, we assume that they are due to the same agent, which we term ‘pain-producing substance’. When an inflammatory exudate is collected in a glass syringe, this substance is not at first detectable, but develops within 2–5 min. The same is true of whole blood, with or without anticoagulant.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Armstrong, D., Dry, R. M. L., Keele, C. A., and Markham, J. W., J. Physiol., 120, 326 (1953).

  2. 2

    Armstrong, D., Hobbiger, F., Jepson, J. B., and Keele, C. A., Abstracts of Communications, XIX Internat. Physiol. Congress. Montreal, 173 (1953).

  3. 3

    Argent, D. E., Armstrong, D., Jepson, J. B., Keele, C. A., and Phillips, L. A., J. Physiol., 124, 18P (1954).

  4. 4

    Rocha e Silva, M., Beraldo, W. T., and Rosenfeld, G., Amer. J. Physiol., 156, 261 (1949).

  5. 5

    Andrade, S. O., Diniz, C. R., and Rocha e Silva, M., Arch. int. pharmacodyn., 95, 100 (1953).

  6. 6

    Werle, E., Kehl, R., and Koebke, K., Biochem. Z., 321, 213 (1950).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

ARMSTRONG, D., KEELE, C., JEPSON, J. et al. Development of Pain-producing Substance in Human Plasma. Nature 174, 791–792 (1954) doi:10.1038/174791a0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.