Secretion of Aldosterone and Corticosterone by the Rat Adrenal


A STUDY has been made of the nature and regulation of rat adrenal steroid secretion. The adrenal-vein blood of rats was collected, extracted and chromatographed by the method of Bush1,2. Corticosterone was detected and estimated by the soda-fluorescence reaction1. Mineralocorticoid activity was estimated by the biological method of Simpson and Tait3.

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    Bush, I. E., Biochem. J., 50, 370 (1952).

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    Bush, I. E., J. Endocrin., 9, 95 (1953).

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    Simpson, S. A., and Tait, J. F., Endocrinology, 50, 150 (1952).

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    Simpson, S. A., and Tait, J. F., Mem. Soc. Endocrinology, London, 2, 9 (1953).

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    Simpson, S. A., Tait, J. F., Wettstein, A., Neher, R., Euw, J. v., Schendler, O., and Reichstein, T., Helv. Chim. Acta, 37, 1163 (1954).

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    Deane, H. W., Shaw, J. H., and Greep, R. O., Endocrinology, 43, 133 (1948).

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SINGER, B., STACK-DUNNE, M. Secretion of Aldosterone and Corticosterone by the Rat Adrenal. Nature 174, 790–791 (1954).

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