Abstract
Paton and Perry1 demonstrated a competitive antagonism between acetyl oholine and penta-methyline bis-trimethyl ammonium dibromide (pentamethonium), at ganglia, and this suggested that pentamethonium might be of value in treating poisoning with antioholinesterases such as diethyl 4-nitrophenyl phosphate (paraoxon). Douglas and Matthews2 used pentamethonium in cats poisoned with tetraethyl pyrophosphate (TEPP), and showed that it improved the contractile power of the diaphragm. We now have evidence that pentamethonium bromide significantly increases survival of fully atropinized animals—mice, rabbits and cats— poisoned with paraoxon.
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References
Paton, W. D. M., and Perry, W. L. M., J. Physiol., 112, 48 P (1951); 119, 43 (1953).
Douglas, W. W., and Matthews, P. B. C., J. Physiol., 116, 202 (1952).
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DE CANDOLE, C., MCPHAIL, M. Pentamethonium as an Adjuvant to Atropine in the Therapy of Paraoxon Poisoning. Nature 174, 552–553 (1954). https://doi.org/10.1038/174552a0
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DOI: https://doi.org/10.1038/174552a0
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