Abstract
THE fully formed collagen fibrils of connective tissue in adult animals are known to have a very slow rate of metabolic turnover1. Recently, evidence has been presented for the existence of a soluble precursor of collagen of high turnover-rate2. By contrast, I have been unable to find any published information about the metabolism of elastin—another important connective-tissue protein which is a major constituent of the larger arteries and certain spinal ligaments. The following experiments were therefore conducted to supply some information on elastin metabolism.
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References
Neuberger, A., and Slack, H. G. B., Biochem. J. 53, 47 (1953).
Harkness, R. D., Marko, A. M., Muir, H. M., and Neuberger, A., Biochem. J., 56, 558 (1954).
Slack, H. G. B., Clin. Sci., 13, 155 (1954).
Tunbridge, R. E., Tattersall, R. N., Hall, D. A., Astbury, W. T., and Reed, R., Clin. Sci., 2, 315 (1952).
Neuberger, A., Perrone, J. C., and Slack, H. G. B., Biochem. J., 49, 199 (1951).
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SLACK, H. Metabolism of Elastin in the Adult Rat. Nature 174, 512–513 (1954). https://doi.org/10.1038/174512a0
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DOI: https://doi.org/10.1038/174512a0
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