STUDIES of aqueous systems of intact deoxyribonucleoproteins1 showed that they were markedly unstable. Storage at 2°–5° C. for 24–36 hr. produced a substantial depolymerization of the deoxyribonucleic acid component. This is in marked contrast to the stability of dissociated nucleoproteins in 1.0 M sodium chloride. It was felt that this instability might be functionally significant in the mechanism of radiation effects on biological systems. Studies were therefore made of the effects of X-radiation on aqueous nucleoprotein gels.
Bernstein, M. H., and Mazia, D., Biochim. Biophys. Acta, 10, 600 (1953); 11, 59 (1953).
Kaufmann, B. P., et al., Carnegie Institution of Washington Year Book No. 50, 203 (1951).
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BERNSTEIN, M. Deoxyribonucleoproteins of Cell Nuclei: Sensitivity to X-Rays. Nature 174, 463 (1954). https://doi.org/10.1038/174463a0
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