Abstract
IN the preparation of diphtheria vaccine, the commonly used method involves treatment of the crude toxin with formaldehyde followed by purification of the toxoid by usually rather laborious methods, for example, precipitation at the isoelectric point with methanol in the cold.
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References
French, D., and Edsall, J. T., “Adv. in Protein Chem.”, 2, 278 (1945).
Ericsson, H., and Neumüller, C., Acta Path. et Microbiol. Scand., 31, 124 (1952).
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NEUMÜLLER, C. Detoxification of Diphtheria Toxin with Formaldehyde mixed with an Amino-Acid. Nature 174, 405–406 (1954). https://doi.org/10.1038/174405a0
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DOI: https://doi.org/10.1038/174405a0
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