Abstract
ACCORDING to Waldenström, Fink and Hoerburger1, uroporphyrin I does not pass from aqueous solutions into ethyl acetate at any pH, thus differing from uroporphyrin III, which is readily extracted by ethyl acetate around pH 3.1. This statement has been widely accepted in the literature. We have found, however, that uroporphyrin I in the concentrations studied is readily extracted into ethyl acetate from aqueous solutions at pH 3.0–3.2, and, provided these are strongly buffered, quantitative recoveries can be obtained.
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Waldenström, J., Fink, H., and Hoerburger, W., Z. physiol. Chem., 233, 1 (1935).
Rimington, C., and Sveinsson, S. L., J. Clin. Lab. Invest., 2, 209 (1950).
Falk, J. E., Dresel, E. I. B., and Rimington, C., Nature, 172, 292 (1953). Dresel, E. I. B., and Falk, J. E., Nature, 172, 1185 (1953).
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DRESEL, E., TOOTH, B. Solubility of Uroporphyrin I in Ethyl Acetate. Nature 174, 271 (1954). https://doi.org/10.1038/174271a0
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DOI: https://doi.org/10.1038/174271a0
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