Abstract
IT has been stated by Sutherland and de Duve1 that the hyperglycæmic glycogenolytic factor of the pancreas is formed in the alpha cells of the islet tissue. Presence of an identical factor in the gastric mucosa led the same workers to suggest that the argentophil cells of the gastric mucosa, a cell-type believed by some investigators2 to be identical with the alpha cells of the pancreas, might also be the site of formation of this factor. The recent discovery that cobalt chloride selectively destroys the alpha cells3 but not the argentophil cells4 has, however, thrown doubt on the morphological relationship of these cells. The specific site of formation of the hyperglycæmic glycogenolytic factor has not yet been definitely established. The investigations reported here appear to throw further light on this controversial point.
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References
Sutherland, E. W., and de Duve, Christian, J. Biol. Chem., 175, 663 (1948).
Tehver, J., Z. mikr-anat. Forsch., 21, 462 (1930).
Van Campenhout, E., and Cornelis, G., C.R. Soc. Biol., Paris, 1, 45/11–12, 933 (1951).
Fodden, J. H., Amer. J. Clin. Path., 23, 10, 994 (1953).
Sutherland, E. W., Cori, C. F., Haynes, R., and Olsein, N. S., J. Biol. Chem., 180, 825 (1949).
de Duve, Christian, and Vuylsteke, Ch., J. Physiol. (Paris), 45/1, 107 (1953).
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RAO, M., DE, N. Abdominal Lymphatic Tissue as a Source of Hyperglycæmic Glycogenolytic Factor. Nature 174, 229–230 (1954). https://doi.org/10.1038/174229b0
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DOI: https://doi.org/10.1038/174229b0
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