Abstract
THE enhancement of the phenotypic expression of delayed mutations has been reported by Witkin1. The purpose of the present communication is to describe the suppression by glycine of the phenotypic expression of a mutant with a partial requirement for glycine. Such strains arise by partial reversion of an E. coli mutant which is entirely dependent upon glycine or serine2,3. It can be shown on solid media (where selection phenomena are limited since the cells are spatially fixed) that the growth of a partially reverted strain, as well as mutations to increasingly independent types, is suppressed in minimal medium if the strain was previously grown in the presence of glycine.
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References
Witkin, Evelyn M., Genetics, 35, 141 (1950).
Wright, Barbara E., Nature, 168, 1087 (1951).
Wright, Barbara E., C.R. Lab. Carlsberg, Sér. Phys., 25, 173 (1953).
Wright, Barbara E., J. Bact. (in the press).
Wijesundera, S., and Woods, D. D., unpublished work quoted by D. D. Woods, First Marjory Stephenson Memorial Lecture, London (1953).
Cohn, M., Cohen, G. N., and Monod, J., C.R. Acad. Sci., Paris, 236, 746 (1953).
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WRIGHT, B. Specific Suppression by Glycine of the Phenotypic Expression of Partially Reverted Glycineless E. coli Mutants. Nature 172, 308–309 (1953). https://doi.org/10.1038/172308a0
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DOI: https://doi.org/10.1038/172308a0
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