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Intolerance of Dizygotic Twin Lambs to Skin Homografts

Abstract

IT has been shown that homografts exchanged between dizygous cattle twins may often survive indefinitely in spite of the fact that grafts exchanged between full siblings other than twins, or between calves and dam, have not been found to survive more than twenty days after transplantation1,2. This anomalous tolerance on the part of dizygous cattle twins is thought to have the same origin as their conformity of red-cell agglutination types3,4, namely, the confluence of their fœtal circulations. The purpose of the present inquiry was to determine whether dizygous sheep twins are also tolerant to grafts of each other's skin.

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References

  1. Anderson, D., Billingham, R. E., Lampkin, G. H., and Medawar, P. B., Heredity, 5, 379 (1951).

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  2. Billingham, R. E., Lampkin, G. H., Medawar, P. B., and Williams, H. Ll., Heredity, 6, 201 (1952).

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  3. Owen, R. D., Science, 102, 400 (1945).

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  5. Johansson, I., and Hansson, A., Lantbrukshögskolans Annaler, Uppsala, 11, 145 (1943).

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LAMPKIN, G. Intolerance of Dizygotic Twin Lambs to Skin Homografts. Nature 171, 975–976 (1953). https://doi.org/10.1038/171975b0

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