Abstract
A SINGLE application of a carcinogenic hydrocarbon, in itself insufficient to cause tumours, can bring about a change in mouse skin enabling subsequent applications of the non-carcinogenic substance croton oil to result in the formation of papillomas and carcinomas1. It seemed of interest to inquire whether a ‘latent’ tumour change similar to that produced by the hydrocarbon could be induced in mouse skin by the local application of beta-rays in a single, subcarcinogenic dose.
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References
Berenblum, I., and Shubik, P., Brit. J. Cancer, 1, 383 (1947).
Raper, J. R., Henshaw, P. S., and Snider, R. S., chapter 13 in “Biological Effects of External Beta Radiation”, edit. R. E. Zirkle (McGraw-Hill Book Co., Inc., 1951).
Glücksmann, A., “Biological Hazards of Atomic Energy”, edit. A. Haddow (Clarendon Press, Oxford, 1952).
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SHUBIK, P., GOLDFARB, A., RITCHIE, A. et al. Latent Carcinogenic Action of Beta-Irradiation on Mouse Epidermis. Nature 171, 934–935 (1953). https://doi.org/10.1038/171934a0
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DOI: https://doi.org/10.1038/171934a0
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