Distribution of Substance P in the Central and Peripheral Nervous System


SUBSTANCE P is a biologically active polypeptide found in extracts of brain and intestine1,2. It causes a transient fall of the blood pressure and stimulation of smooth muscle even in the presence of atropine and antihistamine drugs. Purified preparations exert biological effects even in concentrations of 1 µgm. per ml. The present communication deals with its distribution in the nervous system.


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PERNOW, B. Distribution of Substance P in the Central and Peripheral Nervous System. Nature 171, 746 (1953). https://doi.org/10.1038/171746a0

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