Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Role of Choline in the Oxidation of Fatty Acids by the Isolated Liver


THE lipotropic effect of choline has been interpreted most generally by assuming that fatty acids are carried out of the liver in the form of plasma phospholipides. However, the role of these compounds in the transport of fatty acids has been questioned1. The results presented here strongly suggest that choline acts by enhancing the oxidation of fatty acids in the liver.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Entenman, C., Chaikoff, I. L., and Zilversmit, D. B., J. Biol. Chem., 166, 15 (1946). Zilversmit, D. B., Entenman, C., and Chaikoff, I. L., J. Biol. Chem., 176, 193 (1948).

    CAS  PubMed  Google Scholar 

  2. Artom, C., and Cornatzer, W. E., J. Biol. Chem., 171, 797 (1947).

    Google Scholar 

  3. Weinhouse, S., Millington, R. H., and Volk, M. E., J. Biol. Chem., 185, 191 (1950).

    CAS  PubMed  Google Scholar 

  4. See also, in this respect, Abdon, N. O., and Börglin, N. E., Acta Pharmacol. Toxicol., 3, 73 (1947).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

ARTOM, C. Role of Choline in the Oxidation of Fatty Acids by the Isolated Liver. Nature 171, 347–348 (1953).

Download citation

  • Issue Date:

  • DOI:


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing