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Role of Choline in the Oxidation of Fatty Acids by the Isolated Liver

Abstract

THE lipotropic effect of choline has been interpreted most generally by assuming that fatty acids are carried out of the liver in the form of plasma phospholipides. However, the role of these compounds in the transport of fatty acids has been questioned1. The results presented here strongly suggest that choline acts by enhancing the oxidation of fatty acids in the liver.

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References

  1. Entenman, C., Chaikoff, I. L., and Zilversmit, D. B., J. Biol. Chem., 166, 15 (1946). Zilversmit, D. B., Entenman, C., and Chaikoff, I. L., J. Biol. Chem., 176, 193 (1948).

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  2. Artom, C., and Cornatzer, W. E., J. Biol. Chem., 171, 797 (1947).

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  3. Weinhouse, S., Millington, R. H., and Volk, M. E., J. Biol. Chem., 185, 191 (1950).

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  4. See also, in this respect, Abdon, N. O., and Börglin, N. E., Acta Pharmacol. Toxicol., 3, 73 (1947).

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ARTOM, C. Role of Choline in the Oxidation of Fatty Acids by the Isolated Liver. Nature 171, 347–348 (1953). https://doi.org/10.1038/171347b0

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