Abstract
I HAVE been searching for an appropriate method of oxidizing methionine from biological materials with hydrogen peroxide in order to be able to detect the amino-acid as its sulphone on paper chromatograms as a discrete spot. During the course of this work, it has been found that the heating of methionine in solutions of hydrogen peroxide leads to the formation of several ninhydrin-reacting substances, some of which are of biological interest as possible intermediates in the metabolism of methionine in animal organisms. In the present communication the procedures employed to effect the degradation of methionine, and the results obtained in a preliminary identification of the substances thus produced, are described.
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References
Williams, R. J., and Kirby, H., Science, 107, 481 (1948).
Crumpler, E. R., and Dent, C. E., Nature, 164, 441 (1949).
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MATSUO, Y. Degradation of Methionine by Hydrogen Peroxide. Nature 171, 1021–1022 (1953). https://doi.org/10.1038/1711021a0
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DOI: https://doi.org/10.1038/1711021a0
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