Abstract
DIGESTION of human, ox and horse plasma or digestion for 5 hr. at 37° C. of hypertensinogen (alpha-2 globulin) at pH 2.5–3.5 with crystallized pepsin (50 mgm. per litre) leads to the liberation of several peptides. These substances have been shown to have similar pharmacological effects to those produced by neurohypophysial extracts. Croxatto and Croxatto1 have demonstrated that digestion of hypertensinogen with pepsin produces, under certain conditions, pepsitensin. The latter substance behaves similarly to hypertensin with regard to the action of proteolytic enzymes and tissue extracts.
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References
Croxatto, H., and Croxatto, R., Science, 95, 101 (1942).
Croxatto, H., Almeyda, M., and Barnafi, L. (unpublished observations).
Croxatto, H., Rev. Med. Aliment., 5, 9 (1943).
Croxatto, H., Rojas, G., and Barnafi, L., Acta Physiol. Lat.-Amer., 1, 178 (1951).
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CROXATTO, H., BARNAFI, L., ROJAS, G. et al. Anti-diuretic and Oxytocic Substances liberated by the Digestion of Plasmatic Proteins with Pepsin. Nature 171, 82–83 (1953). https://doi.org/10.1038/171082a0
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DOI: https://doi.org/10.1038/171082a0
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