Abstract
IN living systems a transfer of amino groups occurs between certain amino-acids and keto-acids. This important reversible process, known as ‘transamination’1, effects a link between carbohydrate and protein metabolism, and the responsible enzymes, the transaminases, are activated by pyridoxal2 or pyridoxamine phosphates3. The proposed mechanisms of the reaction involve participation of a Schiff base between amino- and keto-acids4 or between amino-acids and pyridoxal phosphate5. Prototropic rearrangement followed by hydrolysis gives, respectively, the keto- and amino-acids or the keto-acid and pyridoxamine phosphate, the latter then undergoing a reverse reaction with a different keto-acid. A reversible, non-enzymic reaction between pyridoxal and amino-acids to give pyridoxamine and keto-acids, discovered by Snell6, was shown recently to be catalysed by trace metals (copper, iron, aluminium)7. Interest in this chemical process lies mainly in its possible connexion with the biological one ; therefore an explanation of the part played by metals in such reactions is clearly desirable.
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References
Braunstein and Kritzmann, Enzymologia, 2, 129 (1937).
Schlenk and Snell, J. Biol. Chem., 157, 425 (1945). Lichstein, Gunsalus and Umbreit, ibid., 161, 311 (1945).
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Pfeiffer, Breith, Lübbe and Tsumaki, Ann., 503, 84 (1933).
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BADDILEY, J. Pyridoxal Derivatives in Transamination. Nature 170, 711–712 (1952). https://doi.org/10.1038/170711a0
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DOI: https://doi.org/10.1038/170711a0
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