Abstract
WORKING on suggestions put forward by Schmidt and by Swartholm, a number of French and English workers, notably A. Pullman, B. Pullman, P. Daudel, R. Daudel and C. A. Coulson, have developed a hypothesis relating the carcinogenic power of polycyclic aromatics to the structures of these compounds on the basis of quantum mechanics. Evidence has been accumulating in recent years which does indicate a fair correlation to exist between the reactivity calculated for the most reactive double bond in these molecules and their carcinogenicity. The reactive region thus supposed to be mainly responsible for neoplastic activity is usually termed the K-region.
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References
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KOOYMAN, E., HERINGA, J. Extension of the K-Region Hypothesis of Carcinogenic Chemical Compounds. Nature 170, 661–662 (1952). https://doi.org/10.1038/170661a0
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DOI: https://doi.org/10.1038/170661a0
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