Abstract
THE study of steroid synthesis by micro-organisms and certain oxidations and reductions of reactive groups at positions 3 and 17 of the steroid skeleton have been previously reported1. Turfitt2 has studied more extensive degradations of cholesterol by bacteria and has isolated products in which the side-chain has been removed and ring A opened. We should like to report the application of adaptive bacterial enzymes to the study of the oxidative degradation of steroid hormones.
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References
Ottke, R. C., Tatum, E. L., Zabin, I., and Bloch, K., J. Biol. Chem., 189, 429 (1951). Arnaudi, C., Experientia, 7, 81 (1951).
Turfitt, G. E., Biochem. J., 42, 376 (1948).
McIlwain, H., J. Gen. Microbiol., 2, 288 (1948).
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TALALAY, P., DOBSON, M. & TAPLEY, D. Oxidative Degradation of Testosterone by Adaptive Enzymes. Nature 170, 620–621 (1952). https://doi.org/10.1038/170620a0
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DOI: https://doi.org/10.1038/170620a0
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