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Post Transplant Events

BK-viruria and haemorrhagic cystitis are more frequent in allogeneic haematopoietic stem cell transplant patients receiving full conditioning and unrelated-HLA-mismatched grafts

Bone Marrow Transplantation volume 41, pages 737–742 (2008)Cite this article

Abstract

The influence of conditioning regimen, donor background and HLA matching on development of BK virus (BKV)-associated haemorrhagic cystitis (HC) was examined in 175 allogeneic haematopoietic stem cell transplant (HSCT) patients, undergoing 179 HSCT events. Twenty-seven patients presented late-onset HC, and BK viruria was verified in 23/27 HC events. Seventy-one (40%) HSCTs were performed with myeloablative conditioning (MC), 108 (60%) were performed with reduced intensity conditioning (RIC), 66 (37%) were performed with a related donor (RD) grafts and 113 (63%) with an unrelated donor (URD) graft. BK viruria was more common during HC, than non-HC events, after MC as compared to RIC (both P<0.001), and with an HLA-mismatched donor (P<0.01). By multivariate logistical regression analysis, independent risk factors for HC were BKV (OR 6.7; 95% CI 2.0–21.7; P=0.001), MC (OR 6.0; 95% CI 2.1–17.3; P<0.001) and URD (OR 3.4; 95% CI 1.1–10.6; P=0.03). However, when analysing HSCT performed with URD or RD grafts separately, BKV (OR 8.5; 95% CI 1.8–19.3; P=0.004) and MC (OR 5.9; 95% CI 1.3–11.3; P=0.009) increased the risk for HC only with a URD, but not with an RD graft.

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Acknowledgements

We acknowledge the Children's Cancer Foundation, the Swedish Cancer Foundation, the Stockholm Cancer Society, Karolinska Institutet and the Stockholm City Council for their financial support. We also thank the patients and the staff at the Centre of Allogeneic Stem Cell Transplantation and the Departments of Haematology and Paediatrics for participating in this project.

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Authors and Affiliations

  1. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

    G Giraud, P Priftakis, G Bogdanovic, M Dubrulle, A Hau, R Gutmark & T Dalianis

  2. Department of Paediatrics, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden

    P Priftakis & J Winiarski

  3. Department of Clinical Microbiology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden

    G Bogdanovic

  4. Department of Clinical Immunology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden

    M Remberger, J Mattson & T Dalianis

  5. Johns Hopkins University School of Medicine, Baltimore, MD, USA

    R Gutmark

  6. Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden

    J Mattson, B-M Svahn & O Ringden

  7. Haematology Centre, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden

    P Ljungman

  8. Swedish Institute for Infectious Disease Control, Solna, Sweden

    T Dalianis

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  1. G Giraud
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  2. P Priftakis
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  3. G Bogdanovic
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Correspondence to T Dalianis.

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Giraud, G., Priftakis, P., Bogdanovic, G. et al. BK-viruria and haemorrhagic cystitis are more frequent in allogeneic haematopoietic stem cell transplant patients receiving full conditioning and unrelated-HLA-mismatched grafts. Bone Marrow Transplant 41, 737–742 (2008). https://doi.org/10.1038/sj.bmt.1705962

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  • DOI: https://doi.org/10.1038/sj.bmt.1705962

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