Abstract
Autologous or allogeneic SCT with conventional conditioning (chemotherapy with or without irradiation) has emerged as an effective and potentially curative therapy in patients with hematologic malignancies and in other selected solid tumors; however, several patients experience significant early and delayed side effects, including long-term endocrine imbalance and infertility. In spite of several reproductive recovery and pregnancy reports published in the oncology literature, review of medical literature reveals a paucity of comparable information in the SCT field. We report here four cases of ovarian recovery in patients who received hormonal replacement therapy after diagnosis of primary ovarian failure due to high-dose chemotherapy and SCT.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Appelbaum FR, Herzig GP, Ziegler JL, Graw RG, Levine AS, Deisseroth AB . Successful engraftment of cryopreserved autologous bone marrow in patients with malignant lymphoma. Blood 1978; 52: 85–95.
Schimmer AD, Quatermain M, Imrie K, Ali V, McCrae J, Stewart K et al. Ovarian function after autologous bone marrow transplantation. J Clin Oncol 1998; 16: 2359–2363.
Gulati SC, Poznak CV . Pregnancy after bone marrow transplantation. J Clin Oncol 1998; 16: 1978–1985.
Sanders JE, Hawley J, Levy W, Gooley T, Buckner CD, Deeg HJ et al. Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation. Blood 1996; 87: 3045–3052.
Tauchmanova L, Selleri C, Rosa GD, Pagano L, Orio F, Lombardi G et al. High prevalence of endocrine dysfunction in long-term survivors after allogeneic bone marrow transplantation for hematologic diseases. Cancer 2002; 95: 1076–1084.
Tauchmanova L, Selleri C, Rosa GD, Esposito M, Palomba S, Bifulco G et al. Gonadal status in reproductive age women after hematopoietic stem cell transplantation for hematological malignancies. Hum Reprod 2003; 18: 1410–1416.
Sklar C . Growth and endocrine disturbances after bone marrow transplantation in childhood. Acta Paediatr 1995; 411 (Suppl): 57–61.
Brennan BMD, Shalet SM . Endocrine late effects after bone marrow transplant. Br J Haematol 2002; 118: 58–66.
Sanders JE, Buckner CD, Amos D, Levy W, Appelbaum FR, Doney K et al. Ovarian function following marrow transplantation for aplastic anemia or leukemia. J Clin Oncol 1988; 6: 813–818.
Piccioni P, Scirpa P, D'Emilio I, Sora F, Scarciglia M, Laurenti L et al. Hormonal replacement therapy after stem cell transplantation. Maturitas 2004; 49: 327–333.
Apperley JF, Reddy N . Mechanism and management of treatment-related gonadal failure in recipients of high dose chemo radiotherapy. Blood Rev 1995; 9: 93–116.
Beral V, Banks E, Reeves G . Evidence from randomised trials on the long-term effects of hormone replacement therapy. Lancet 2002; 360: 942.
Miller J, Chan BK, Nelson HD . Postmenopausal estrogen replacement and risk for venous thromboembolism: a systematic review and meta-analysis for the US Preventive Services Task Force. Ann Intern Med 2002; 136: 680–690.
Somers EC, Marder W, Christman GM, Ognevovski V, McCune WJ . Use of gonadotrophin-releasing hormone analog for protection against premature ovarian failure during cyclophosphamide therapy in women with severe lupus. Arthritis Rheum 2005; 52: 2761–2767.
Blumenfeld Z . Gynaecologic concerns for young women exposed to gonadotoxic chemotherapy. Curr Opin Obstet Gynecol 2003; 15: 359–370.
Peng C, Fan NC, Ligier M, Vaananen J, Leung PC . Expression and regulation of gonadotropin-releasing hormone (GnRH) and GnRH receptor messenger ribonucleic acids in human granulose luteal cells. Endocrinology 1994; 135: 1740–1746.
Blumenfeld Z, Avivi I, Linn S, Epelbaum R, Shahar BM, Haim N . Prevention of irreversible chemotherapy-induced ovarian damage in young women with lymphoma by a gonadotrophin-releasing hormone agonist in parallel to chemotherapy. Hum Reprod 1996; 11: 1620–1626.
Blumenfeld Z, Avivi I, Ritter M, Rowe MJ . Preservation of fertility and ovarian function and minimizing chemotherapy-induced gonadotoxicity in young women. J Soc Gynecol Investig 1999; 6: 229–239.
Recchia F, Sica G, De Filippis S, Saqqio G, Rosselli M, Rea S . Goserelin as ovarian protection in the adjuvant treatment of premenopausal breast cancer: a phase II pilot study. Anticancer Drugs 2002; 13: 417–424.
Franke HR, Smit WM, Vermes I . Gonadal protection by a gonadotropin-releasing hormone agonist depot in young women with Hodgkin's disease undergoing chemotherapy. Gynecol Endocrinol 2005; 20: 274–278.
Salooja N, Szydlo RM, Socie G, Rio B, Chatterjee R, Ljungman P et al. Pregnancy outcomes after peripheral blood or bone marrow transplantation: a retrospective survey. Lancet 2001; 358: 271–277.
Salooja N, Chatterjee R, McMillan AK, Kelsey SM, Newland AC, Milligan DW et al Successful pregnancies in women following single auto transplant for acute myeloid leukemia with a chemotherapy ablation protocol. Bone Marrow Transplant 1994; 13: 431–435.
Jackson GH, Wood A, Taylor PR, Lennard AL, Lucraft H, Heppleston A et al. Early high-dose chemotherapy intensification with autologous bone marrow transplantation in lymphoma associated with retention of fertility and normal pregnancies in females. Scotland and Newcastle lymphoma group, UK. Leuk Lymphoma 1997; 28: 127–132.
Brice P, Haioun C, Andre M, Gisselbrecht C . Pregnancies after high-dose chemotherapy and autologous stem cell transplantation in aggressive lymphoma. Blood 2002; 100: 736.
Chatterjee R, Kottaridis PD . Treatment of gonadal damage in recipients of allogeneic or autologous transplantation for hematological malignancies. Bone Marrow Transplant 2002; 30: 629–635.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Liu, J., Malhotra, R., Voltarelli, J. et al. Ovarian recovery after stem cell transplantation. Bone Marrow Transplant 41, 275–278 (2008). https://doi.org/10.1038/sj.bmt.1705893
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1705893
Keywords
This article is cited by
-
Late endocrine effects after hematopoietic stem cell transplantation in children with nonmalignant diseases
Bone Marrow Transplantation (2022)
-
Fertility considerations in targeted biologic therapy with tyrosine kinase inhibitors: a review
Journal of Assisted Reproduction and Genetics (2021)
-
Prevalence of menstrual cycles and outcome of 50 pregnancies after high-dose chemotherapy and auto-SCT in non-Hodgkin and Hodgkin lymphoma patients younger than 40 years
Bone Marrow Transplantation (2015)
-
Risks, Benefits, and Therapeutic Potential of Hematopoietic Stem Cell Transplantation for Autoimmune Diabetes
Current Diabetes Reports (2012)
-
Successful pregnancy and childbirth after reduced-intensity conditioning and partially HLA-mismatched BMT
Bone Marrow Transplantation (2009)