Abstract
IN 1947, Wright1 (Mrs. M. E. Wallace) reported the remarkable discovery of recombination frequencies exceeding 50 per cent in linkage group VII of the house mouse. Such a phenomenon had been predicted as a theoretical possibility by Jennings2 in 1923 for substantially the right reasons, although he based his argument on a theory of two-strand crossing-over and a simplified discontinuous theory of interference. Mrs. Wallace found that the genetic markers sh2 (shaker-2) and wv2 (waved-2), which show loose linkage with each other of about 30 per cent recombination frequency, both recombined with sex with a frequency of about 56 per cent. This finding was the first case of partial sex-linkage to be reported in any mammal other than man. Rex (symbol Re), which was known to be about 20 per cent from sh2 and about 40 per cent from wv2, assorted independently of sex in other data from the same department.
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References
Wright, M. E. (Mrs. M. E. Wallace), Heredity, 1, (3), 349 (1947).
Jennings, H. S., Genetics, 8, 393 (1923).
Fisher, R. A., Lyon, M. F., and Owen, A. R. G., Heredity, 1, (3), 355 (1947).
Carter, T. C. (personal communication, 1951).
Heston, W. E., J. Hered., 42, (2), 71 (1951).
Fisher, R. A., “The Design of Experiments”, section 70 (London, 6th edit., 1951).
Slizynski, B. M., J. Genet., 49, 242 (1949).
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MICHIE, D. A New Linkage in the House Mouse: Vestigial and Rex. Nature 170, 585–586 (1952). https://doi.org/10.1038/170585a0
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DOI: https://doi.org/10.1038/170585a0
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