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Post-Transplant Events

Acute renal failure after allogeneic myeloablative stem cell transplantation: retrospective analysis of incidence, risk factors and survival

Bone Marrow Transplantation volume 39, pages 359–365 (2007)Cite this article

Abstract

Acute renal failure (ARF) is an important complication after stem cell transplantation (SCT). We retrospectively analysed ARF in 363 recipients of allogeneic myeloablative SCT to identify incidence, risk factors, associated post-transplantation complications and mortality of ARF. ARF was graded as grade 0 (no ARF) to grade 3 (need for dialysis) according to creatinine, estimated glomerular filtration rate and need for dialysis. The incidence of severe renal failure (grades 2 and 3 combined) was 49.6% (180 of 363 patients). Hypertension present at SCT was identified as a risk factor for ARF (P=0.003). Despite this, survival of these patients was not different compared to patients without hypertension. Admission to the intensive care unit (ICU) was a post-transplantation complication significantly associated with ARF (P<0.001). Survival rate was highest in patients with ARF grade 0–1 and lowest in patients with grade 3 (P<0.001). However, after correction for complications associated with high mortality (admission to the ICU, thrombotic thrombocytopenic purpura, sinusoidal occlusion syndrome (SOS) and acute graft-versus-host disease) the significant difference in survival disappeared, showing that ARF without co-morbid conditions has a good prognosis, and ARF with co-morbid conditions has a poor prognosis. This poor prognosis is due to the presence of co-morbid conditions rather than development of ARF itself.

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Acknowledgements

We thank Dr P Westers, Centre of Biostatistics University Utrecht, for expert statistical assistance. We are also grateful to MI Gerrits, J vd Giessen and Dr E Meijer (Department of Haematology, University Medical Centre Utrecht) for providing data.

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Authors and Affiliations

  1. Department of Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands

    S Kersting & L F Verdonck

  2. Department of Nephrology, University Medical Centre Utrecht, Utrecht, The Netherlands

    H A Koomans & R J Hené

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  1. S Kersting
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  2. H A Koomans
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  3. R J Hené
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  4. L F Verdonck
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Correspondence to S Kersting.

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Kersting, S., Koomans, H., Hené, R. et al. Acute renal failure after allogeneic myeloablative stem cell transplantation: retrospective analysis of incidence, risk factors and survival. Bone Marrow Transplant 39, 359–365 (2007). https://doi.org/10.1038/sj.bmt.1705599

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