Abstract
This study was performed to investigate the therapeutic effect of umbilical cord serum eyedrops on dry eye associated with graft-versus-host disease (GVHD). Twenty-four eyes of 12 patients with severe dry eye syndrome associated with GVHD were treated with 20% umbilical cord serum eyedrops. Symptom scoring, corneal sensitivity test, tear film break up time (BUT), Schirmer test, tear clearance rate (TCR), and corneal fluorescein staining were performed before and 2 and 6 months after treatment. Six months after treatment, significant improvement was observed in symptom score (from 3.83±0.38 to 0.83±0.57, P<0.01), corneal sensitivity (from 52.08±6.06 mm to 57.50±3.00 mm, P<0.01), tear film BUT (from 2.50±0.91 s to 5.71±1.04 s, P<0.01), and keratoepitheliopathy score (from 7.42±2.02 to 1.29±0.46, P<0.01). There was no siginificant change in Schirmer test and TCR results. No significant complications associated with the use of the eyedrops were observed. Umbilical cord serum eyedrops are safe and may be an effective way to treat severe dry eye associated with GVHD.
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References
Anderson NG, Regillo C . Ocular manifestations of graft versus host disease. Curr Opin Ophthalmol 2004; 15: 503–507.
Johnson DA, Jabs DA . The ocular manifestations of graft-versus-host diseases. Int Ophthalmol Clin 1997; 37: 119–133.
Ogawa Y, Okamoto S, Wakui M, Watanabe R, Yamada M, Yoshino M et al. Dry eye after hematopoietic stem cell transplantation. Br J Ophthalmol 1999; 83: 1125–1130.
Kiang E, Tesavibul N, Yee R, Kellaway J, Przepiorka D . The use of topical cyclosporin A in ocular graft-versus-host disease. Bone Marrow Transplant 1998; 22: 147–151.
Murphy PT, Sivakumaran M, Fahy G, Hutchinson RM . Successful use of topical retinoic acid in severe dry eye due to chronic graft-versus-host disease. Bone Marrow Transplant 1996; 18: 641–642.
Ogawa Y, Okamoto S, Kuwana M, Mori T, Watanabe R, Nakajima T et al. Successful treatment of dry eye in two patients with chronic graft-versus-host disease with systemic administration of FK506 and corticosteroids. Cornea 2001; 20: 430–434.
Ogawa Y, Okamoto S, Mori T, Yamada M, Mashima Y, Watanabe R et al. Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease. Bone Marrow Transplant 2003; 31: 579–583.
Poon AC, Geerling G, Dart JK, Fraenkel GE, Daniels JT . Autologous serum eyedrops for dry eye and epithelial defect: clinical and in vitro toxicity studies. Br J Ophthalmol 2001; 85: 1188–1197.
Rocha EM, Pelegrino FSA, de Paiva CS, Vigorito AC, de Souza CA . GVHD dry eyes treated with autologous serum tears. Bone Marrow Transplant 2000; 25: 1101–1103.
Yoon KC, Im SK, Park YG, Jung YD, Yang SY, Choi J . Application of umbilical cord serum eyedrops for the treatment of dry eye syndrome. Cornea 2006; 25: 268–272.
Yoon KC, Heo H, Jeong IY, Park YG . Therapeutic effect of umbilical cord serum eyedrops for persistent corneal epithelial defect. Korean J Ophthalmol 2005; 19: 174–178.
Tsubota K, Goto E, Fujita H, Ono M, Inoue H, Saito I et al. Treatment of dry eye by autologous serum application in Sjogren's syndrome. Br J Ophthalmol 1999; 83: 390–395.
Dogru M, Katakami C, Inoue M . Tear function and ocular surface changes in noninsulin-dependent diabetes mellitus. Ophthalmology 2001; 108: 568–592.
Tsubota K . Tear dynamics and dry eye. Prog Retin Eye Res 1998; 17: 565–596.
Miyata K, Amano S, Sawa M, Nishida T . A novel grading method for superficial punctate keratopathy magnitude and its correlation with cornea epithelial permeability. Arch Ophthalmol 2003; 121: 1537–1539.
Ogawa Y, Yamazaki K, Kuwana M, Mashima Y, Nakamura Y, Ishida S et al. A significant role of stromal fibroblasts in rapidly progressive dry eye in patients with chronic GVHD. Invest Ophthalmol Vis Sci 2001; 42: 111–119.
Ogawa Y, Kuwana M . Dry eye as a major complication associated with chronic graft-versus-host disease after hematopoietic stem cell transplantation. Cornea 2003; 22: S19–S27.
Peris-Martinez C, Menezo JL, Diaz-Llopis M, Avino-Martinez JA, Navea-Tejerina A, Risueno-Reguillo P . Multilayer amniotic membrane transplantation in severe ocular graft versus host disease. Eur J Ophthalmol 2001; 11: 183–186.
Vajpayee RB, Mukerji N, Tandon R, Sharma N, Pandey RM, Biswas NR et al. Evaluation of umbilical cord serum therapy for persistent corneal epithelial defects. Br J Ophthalmol 2003; 87: 1312–1316.
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Yoon, KC., Jeong, IY., Im, SK. et al. Therapeutic effect of umbilical cord serum eyedrops for the treatment of dry eye associated with graft-versus-host disease. Bone Marrow Transplant 39, 231–235 (2007). https://doi.org/10.1038/sj.bmt.1705566
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DOI: https://doi.org/10.1038/sj.bmt.1705566
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