Table 2 Outcome of HSCT in pediatric ALL following VP16/TBI versus CY/TBI

From: Comparative outcome of hematopoietic stem cell transplantation for pediatric acute lymphoblastic leukemia following cyclophosphamide and total body irradiation or VP16 and total body irradiation conditioning regimens

Parameter VP16/TBI (n=62) CY/TBI (n=45) P-value
Engraftment (days)
 Neutrophils    
Median (range) 18 (10, 33) 17 (10, 28) 0.1
 Platelets    
Median (range) 31 (17, 167) 29 (14, 139) 0.1
3-year TRM
 MRD 20.2±7.6 17.4±12.0 0.4
 MUD 32.6±11.0 22.7±9.0 0.7
3-year relapse
 MRD 40.6±9.4 64.9±13.4 0.2
 MUD 27.6±12.0 16.9±9.1 0.8
3-year EFS by CR
 CR1 58.3±15.5 62.3±15.0 0.7
 CR2 59.1±9.3 50.0±10.3 0.4
 CR3 41.7±14.2 33.3±19.3 0.8
3-year EFS
 MRD 47.4±8.8 29.4±11.9 0.5
 MUD 48.8±11.4 63.7±10.4 0.6
  1. Abbreviations: ALL=acute lymphoblastic leukemia; CR=complete remission; CY=cyclophosphamide; EFS=event-free survival; HSCT=haematopoietic stem cell transplantation; MRD=matched related donor; MUD=matched unrelated donor; TBI=total body irradiation.