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Cytochrome P450 1A2 is a target antigen in hepatitic graft-versus-host disease

Bone Marrow Transplantation volume 38, pages 703–705 (2006)Cite this article

Chronic graft-versus-host disease (GVHD) involving the liver most commonly manifests as indolent cholestasis. However, a hepatitic variant of GVHD with marked transaminitis and lobular inflammation on liver biopsy is now well recognized.1, 2 The pathogenesis of this complication is poorly understood. Here we report a case of hepatitic GVHD with positive autoimmune serology that led to the definition of cytochrome P450 1A2 (CYP1A2) as a target antigen.

Oral prednisolone (50 mg/day) resulted in brisk improvement in hepatitis and oral chronic GVHD, and was ceased at 12 months post transplant. The patient remains well with no further GVHD, 100% donor lymphoid chimerism and normal liver function studies over 3 years post transplant.

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References

  1. Ma SY, Au WY, Ng IO, Lie AK, Leung AY, Liang R et al. Hepatitic graft-versus-host disease after hematopoietic stem cell transplantation: clinicopathologic features and prognostic implication. Transplantation 2004; 77: 1252–1259.

    Article  Google Scholar 

  2. Strasser SI, Shulman HM, Flowers ME, Reddy R, Margolis DA, Prumbaum M et al. Chronic graft-versus-host disease of the liver: presentation as an acute hepatitis. Hepatology 2000; 32: 1265–1271.

    Article  CAS  Google Scholar 

  3. Vergani D, Alvarez F, Bianchi FB, Cancado EL, Mackay IR, Manns MP et al. Liver autoimmune serology: a consensus statement from the committee for autoimmune serology of the International Autoimmune Hepatitis Group. J Hepatol 2004; 41: 677–683.

    Article  Google Scholar 

  4. Bourdi M, Larrey D, Nataf J, Bernuau J, Pessayre D, Iwasaki M et al. Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis. J Clin Invest 1990; 85: 1967–1973.

    Article  CAS  Google Scholar 

  5. Bogdanos DP, Pares A, Baum H, Caballeria L, Rigopoulou EI, Ma Y et al. Disease-specific cross-reactivity between mimicking peptides of heat shock protein of Mycobacterium gordonae and dominant epitope of E2 subunit of pyruvate dehydrogenase is common in Spanish but not British patients with primary biliary cirrhosis. J Autoimmun 2004; 22: 353–362.

    Article  CAS  Google Scholar 

  6. Obermayer-Straub P, Perheentupa J, Braun S, Kayser A, Barut A, Loges S et al. Hepatic autoantigens in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Gastroenterology 2001; 121: 668–677.

    Article  CAS  Google Scholar 

  7. Belloc C, Gauffre A, Andre C, Beaune PH . Epitope mapping of human CYP1A2 in dihydralazine-induced autoimmune hepatitis. Pharmacogenetics 1997; 7: 181–186.

    Article  CAS  Google Scholar 

  8. Robin MA, Maratrat M, Loeper J, Durand-Schneider AM, Tinel M, Ballet F et al. Cytochrome P4502B follows a vesicular route to the plasma membrane in cultured rat hepatocytes. Gastroenterology 1995; 108: 1110–1123.

    Article  CAS  Google Scholar 

  9. Hess AD, Jones RJ . Autologous graft-vs-host disease. In: Blume KG, Forman SJ, Appelbaum FR (eds). Thomas' Hematopoietic Cell Transplantation. Blackwell Publishing Inc.: Malden, 2004, pp 405–413.

    Google Scholar 

  10. Vergani D, Mieli-Vergani G . Autoimmunity after liver transplantation. Hepatology 2002; 36: 271–276.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, St Jude Children's Research Hospital Memphis, Memphis, TN, USA

    C G Mullighan

  2. Division of Hematology, Institute of Medical and Veterinary Science, University of Adelaide, Adelaide, Australia

    C G Mullighan & P G Bardy

  3. Institute of Liver Studies, King's College London School of Medicine at King's College Hospital, King's College, Denmark Hill, London, UK

    D-P Bogdanos & D Vergani

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  1. C G Mullighan
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  2. D-P Bogdanos
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Correspondence to C G Mullighan.

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Mullighan, C., Bogdanos, DP., Vergani, D. et al. Cytochrome P450 1A2 is a target antigen in hepatitic graft-versus-host disease. Bone Marrow Transplant 38, 703–705 (2006). https://doi.org/10.1038/sj.bmt.1705510

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