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Heterogeneous loss of the Y chromosome in leukocyte lineages of donor origin after stem cell transplantation

Bone Marrow Transplantation volume 38, pages 463–465 (2006)Cite this article

Loss of the Y chromosome has been described in patients with hematological malignancies representing a disease-associated chromosome marker.1, 2 However, several studies have shown that loss of the Y chromosome with a resulting 45,X,-Y karyotype from bone marrow (BM) and peripheral blood (PB) cells of elderly males is relatively common (c.a. 8% of males older than 60 years) and in most cases must be interpreted as a normal age-related phenomenon with no pathological consequence.1, 3

Advances of allogeneic stem cell transplantation (SCT), such as reduced intensity conditioning or haploidentical transplant settings, have favored the use of patients and/or donors of increasing age. Therefore, the chance to find healthy donors with loss of the Y chromosome is also increased.

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Acknowledgements

The authors wish to thank Elena Moreno López and Ainhoa Simón Zárate for their excellent technical assistance. This work has been partially supported by grants FIS02-1177 and FIS04-1079 from the Ministerio de Sanidad y Consumo and GR/SAL/0228/2004 from Comunidad de Madrid (Spain).

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  1. Department of Hematology, Gregorio Marañón G. U. Hosp, Madrid, Spain

    I Buño, M Kwon, P Balsalobre, D Serrano, R Carrión, A Gómez-Pineda & J L Díez-Martín

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Buño, I., Kwon, M., Balsalobre, P. et al. Heterogeneous loss of the Y chromosome in leukocyte lineages of donor origin after stem cell transplantation. Bone Marrow Transplant 38, 463–465 (2006). https://doi.org/10.1038/sj.bmt.1705470

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