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A prompt graft-versus-thalassemia effect upon withdrawal of cyclosporine A in a child who received allogeneic peripheral blood stem cell transplantation

Bone Marrow Transplantation volume 38, pages 315–316 (2006)Cite this article

Stable mixed chimerism is a common event in children with thalassemia major who have undergone bone marrow transplantation (BMT). However, persistence of unstable mixed chimerism in these children is associated with a greater risk of rejection and/or relapse of the disease. Andreani et al.1 has reported that rejection and/or disease recurrence occurs in approximately one third of patients with early mixed chimerism in thalassemia major.

Here, we report a child with thalassemia major who developed unstable mixed chimerism associated with rapidly decreasing hemoglobin levels at day +90. Full donor chimerism was achieved promptly after withdrawal of cyclosporine. To the best of our knowledge, this is the first report of a child with thalassemia major in whom unstable mixed chimerism was reversed by only cyclosporine withdrawal.

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Authors and Affiliations

  1. Pediatric Hematology Unit, Hacettepe University School of Medicine, Sıhhiye Ankara, Turkey

    B Tavil, B Kuşkonmaz & M çetin

  2. Hacettepe University School of Medicine, Ihsan Dogramacı Children's Hospital, Sıhhiye Ankara, Turkey

    M Kazık

  3. Pediatric Hematology, Bone Marrow Transplantation Unit, Hacettepe University School of Medicine, Sıhhiye Ankara, Turkey

    D Uçkan

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  1. B Tavil
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Tavil, B., Kazık, M., Kuşkonmaz, B. et al. A prompt graft-versus-thalassemia effect upon withdrawal of cyclosporine A in a child who received allogeneic peripheral blood stem cell transplantation. Bone Marrow Transplant 38, 315–316 (2006). https://doi.org/10.1038/sj.bmt.1705432

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