Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Splenic rupture following administration of pegfilgrastim in a patient with multiple myeloma undergoing autologous peripheral blood stem cell transplantation

Bone Marrow Transplantation volume 38, pages 69–70 (2006)Cite this article

Spontaneous rupture of the spleen is a rare but serious and life-threatening complication of treatment with granulocyte colony-stimulating factor (G-CSF). A few case reports address the occurrence of splenic rupture after filgrastim therapy, mostly in healthy donors of peripheral blood stem cells, but also in patients with acute myelogenous leukemia, myelodysplastic syndrome and amyloidosis.1, 2, 3, 4, 5 A recent article by Arshad et al.6 describes a case of splenic rupture in a patient with myelodysplastic syndrome following administration of pegfilgrastim. The compound has recently been approved to shorten neutropenia and decrease the incidence of infection in patients with non-myeloid malignancies receiving myelosuppressive anticancer drugs. We report a case of splenic rupture in a completely different clinical situation after the use of pegfilgrastim in a patient with multiple myeloma undergoing autologous peripheral blood stem cell transplantation (PBSCT).

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

References

  1. Falzetti F, Aversa F, Minelli O, Tabilio A . Spontaneous rupture of spleen during peripheral blood stem-cell mobilisation in a healthy donor. Lancet 1999; 353: 555.

    CAS  Google Scholar 

  2. Becker PS, Wagle M, Matous S . Spontaneous splenic rupture following administration of granulocyte colony-stimulating factor (G-CSF): occurrence in an allogeneic donor of peripheral blood stem cells. Biol Blood Marrow Transplant 1997; 3: 45–49.

    CAS  Google Scholar 

  3. O'Malley DP, Whalen M, Banks PM . Spontaneous splenic rupture with fatal outcome following G-CSF administration for myelodysplastic syndrome. Am J Hematol 2003; 73: 294–295.

    Article  Google Scholar 

  4. Zimmer BM, Berdel WE, Ludwig WD, Notter M, Rheufi B, Thiel E . Fatal spleen rupture during induction chemotherapy with GM-CSF priming for acute monocytic leukemia. Leuk Res 1993; 17: 277–283.

    CAS  Article  Google Scholar 

  5. Oran B, Wright DG, Seldin DC, McAneny D, Skinner M, Sanchorawala V . Spontaneous rupture of the spleen in AL amyloidosis. Am J Hematol 2003; 74: 131–135.

    CAS  Article  Google Scholar 

  6. Arshad M, Seiter K, Bilaniuk J, Qureshi A, Patil A, Ramaswamy G et al. Side effects related to cancer treatment: CASE 2. Splenic rupture following pegfilgrastim. J Clin Oncol 2005; 23: 8533–8534.

    Article  Google Scholar 

  7. Stroncek D, Shawker T, Follmann D, Leitman SF . G-CSF-induced spleen size changes in peripheral blood progenitor cell donors. Transfusion 2003; 43: 609–613.

    CAS  Article  Google Scholar 

  8. Picardi M, De Rosa G, Selleri C, Scarpato N, Soscia E, Martinelli V et al. Spleen enlargement following recombinant human granulocyte colony-stimulating factor administration for peripheral blood stem cell mobilization. Haematologica 2003; 88: 794–800.

    CAS  PubMed  Google Scholar 

  9. Fukushima N, Nishina H, Koishihara Y, Ohkawa H . Enhanced hematopoiesis in vivo and in vitro by splenic stromal cells derived from the mouse with recombinant granulocyte colony-stimulating factor. Blood 1992; 80: 1914–1922.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, Dusseldorf, Germany

    A Kuendgen, R Fenk, I Bruns, M Dommach, A Hünerlitürkoglu, R Haas & G Kobbe

  2. Department of General and Visceral Surgery, Heinrich-Heine-University, Dusseldorf, Germany

    A Schutte

  3. Institute of Pathology, Heinrich-Heine-University, Dusseldorf, Germany

    R Engers

Authors
  1. A Kuendgen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R Fenk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I Bruns
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M Dommach
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A Schutte
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R Engers
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A Hünerlitürkoglu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. R Haas
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. G Kobbe
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A Kuendgen.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kuendgen, A., Fenk, R., Bruns, I. et al. Splenic rupture following administration of pegfilgrastim in a patient with multiple myeloma undergoing autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 38, 69–70 (2006). https://doi.org/10.1038/sj.bmt.1705382

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1705382

Further reading

Search

Advanced search

Quick links