Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Meeting Report
  • Published:

Topical issues in unrelated donor haematopoietic stem cell transplants: a report from a workshop convened by the Anthony Nolan Trust in London – 2005

Bone Marrow Transplantation volume 37, pages 901–908 (2006)Cite this article

Abstract

Over more than three decades, The Anthony Nolan Trust (ANT) has provided an unrelated donor (UD) for over 4000 children and adults lacking a suitable family member donor, and has remained at the forefront of developments in haematopoietic stem cell transplantation (HSCT) and bone marrow register management. These three decades have seen major changes in clinical practice of UD-HSCT, including new indications, increased use of alternative haematopoietic cell sources, significant improvement of the outcome as a result of better support care, less-toxic conditioning regimens, and better donor selection, and expansion to older patients with higher comorbidities. In order to foster our goal of improving UD-HSCT availability and outcome in a progressively more complex clinical scenario, a new initiative from ANT was launched in 2005 to convene an experts workshop to address the topical issues in this field. Four consecutive panels addressed factors influencing donor selection and transplant outcome, the use of cord blood, regulatory and accreditation issues, and future developments in this field. This report summarizes the discussions held in this workshop, which will likely develop into a periodic event where transplant clinicians, scientists and registry members will meet to share their experience and vision in the field of UD-HSCT.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Gratwohl A, Baldomero H, Schmid O, Horisberger B, Bargetzi M . Urbano-Ispizua A for the JACIE. Change in stem cell source for hematopoietic stem cell transplantation (HSCT) in Europe: a report of the EBMT activity survey 2003. Bone Marrow Transplant 2005; 36: 575–590.

    Article  CAS  PubMed  Google Scholar 

  2. Shaw BE, Barber LD, Madrigal JA, Cleaver S, Marsh SGE . Scoring for HLA matching? A clinical test of HistoCheck. Bone Marrow Transplant 2004; 34: 367–368.

    Article  CAS  PubMed  Google Scholar 

  3. Shaw BE, Marsh SGE, Mayor NP, Russell NH, Madrigal JA . HLA-DP1 matching status has significant implications for recipients of unrelated donor stem cell transplants. Blood 2006; 107: 1220–1226.

    Article  CAS  PubMed  Google Scholar 

  4. Shaw BE, Potter MN, Mayor NP, Pay AL, Smith C, Goldman JM et al. The degree of matching at HLA-DP1 predicts for acute graft-versus-host disease and disease relapse following haematopoietic stem cell transplantation. Bone Marrow Transplant 2003; 31: 1001–1008.

    Article  CAS  PubMed  Google Scholar 

  5. Morishima Y, Sasazuki T, Inoko H, Juji T, Akaza T, Yamamoto K et al. The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from a serologically HLA-A, HLA-B and HLA-DR matched unrelated donors. Blood 2002; 99: 4200–4206.

    Article  CAS  PubMed  Google Scholar 

  6. Petersdorf EW, Gooley TA, Anasetti C, Martin PJ, Smith AG, Mickelson EM et al. Optimizing outcome after unrelated marrow transplantation by comprehensive matching of HLA class I and II alleles in the donor and recipient. Blood 1998; 92: 3515–3520.

    CAS  PubMed  Google Scholar 

  7. Flomenberg N, Baxter-Lowe LA, Confer DL, Fernández-Vina M, Filipovich A, Horowitz M et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood 2004; 104: 1923–1930.

    Article  CAS  PubMed  Google Scholar 

  8. Kollman C, Howe CWS, Anasetti C, Antin JH, Davies SM, Filipovich AH et al. Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age. Blood 2001; 98: 2043–2051.

    Article  CAS  PubMed  Google Scholar 

  9. Boeckh M, Nichols WG . The impact of cytomegalovirus serostatus of donor and recipient before hematopoietic stem cell transplantation in the era of antiviral prophylaxis and preemptive therapy. Blood 2004; 103: 2003–2008.

    Article  CAS  PubMed  Google Scholar 

  10. Gluckman E, Broxmeyer HA, Auerbach AD, Friedman HS, Douglas GW, Devergie A et al. Haematopoietic reconstitution in a patient with Fanconi's anaemia by means of umbilical cord blood from an HLA identical sibling. N Engl J Med 1989; 321: 1174–1178.

    Article  CAS  PubMed  Google Scholar 

  11. Gluckman E, Rocha V, Boyer-Chammard A, Locatelli F, Arcese W, Pasquini R et al. Outcome of cord-blood transplantation from related and unrelated donors: Eurocord Transplant Group and the European Blood and Marrow Transplantation Group. N Engl J Med 1997; 337: 373–381.

    Article  CAS  PubMed  Google Scholar 

  12. Wagner JE, Kerman NA, Steinbuch M, Broxmeyer HE, Gluckman E . Allogeneic sibling umbilical cord blood transplantation in children with malignant and non-malignant disease. Lancet 1995; 346: 214–219.

    Article  CAS  PubMed  Google Scholar 

  13. Rubinstein P, Taylor PE, Scaradavou A, Adamson JW, Migliaccio G, Emanuel D et al. Unrelated placental blood for bone marrow reconstitution: organisation of the placental blood program. Blood Cells 1994; 20: 587–596.

    CAS  PubMed  Google Scholar 

  14. Kurtzberg J, Graham M, Casey J, Olson J, Stevens CE, Rubinstein P . The use of umbilical cord blood in mismatched related and unrelated haemopoietic stem cell transplantation. Blood Cells 1994; 20: 275–283.

    CAS  PubMed  Google Scholar 

  15. Wagner JE . Allogeneic cord blood transplantation. In: Winter JN (ed). Blood Stem Cell Transplantation. Kluwer Academic Publishers: Boston, MA, 1997, pp 187–216.

    Chapter  Google Scholar 

  16. Gluckman E . Current status of umbilical cord blood haemopoietic stem cell transplantation. Exp Hematol 2000; 28: 1197–1205.

    Article  CAS  PubMed  Google Scholar 

  17. Silberstein LE, Jefferies LC . Placental blood banking – a new frontier in transfusion medicine. N Engl J Med 1996; 335: 199–201.

    Article  CAS  PubMed  Google Scholar 

  18. Rubinstein P, Rosenfield RE, Adamson JW, Stevens CE . Stored placental blood for unrelated bone marrow reconstitution. Blood 1993; 81: 1679–1690.

    CAS  PubMed  Google Scholar 

  19. Rocha V, Labopin M, Sanz G, Arcese W, Schwerdtfeger R, Bosi A et al. for the Acute Leukemia Working Party of European Bloodand Marrow Transplant Group and the Eurocord–Netcord Registry. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 2004; 351: 2276–2285.

    Article  CAS  PubMed  Google Scholar 

  20. Laughlin MJ, Eapen M, Rubinstein P, Wagner JE, Zhang M-J, Champlin RE et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 2004; 351: 2265–2275.

    Article  CAS  PubMed  Google Scholar 

  21. Sanz MA . Cord-blood transplantation in patients with leukemia – a real alternative for adults. N Engl J Med 2004; 351: 2328–2330.

    Article  CAS  PubMed  Google Scholar 

  22. Bhattacharya A, Slatter M, Chapman CE, Barge D, Jackson A, Flood TJ et al. Single centre experience of umbilical cord stem cell transplantation for primary immunodeficiency. Bone Marrow Transplant 2005; 36: 295–299.

    Article  CAS  PubMed  Google Scholar 

  23. Slatter M, Bhattacharya A, Flood TJ, Abinum A, Cant AJ, Gennery AR . Use of two unrelated umbilical cord stem cell units in stem cell transplantation for Wiskott Aldrich syndrome. Ped Blood Cancer, July 8, 2005 [E-pub ahead of print].

  24. Bhattacharya A, Slatter M, Curtis A, Chapman CE, Barge D, Jackson A et al. Successful umbilical cord blood stem cell transplantation for chronic granulomatous disease. Bone Marrow Transplantation 2003; 31: 403–405.

    Article  CAS  PubMed  Google Scholar 

  25. Staba SL, Escolar ML, Poe M, Kim Y, Martin PL, Szabolcs P et al. Cord blood transplants from unrelated donors in patients with Hurler's syndrome. N Engl J Med 2004; 350: 1960–1969.

    Article  CAS  PubMed  Google Scholar 

  26. Takahashi S, Iseki T, Ooi J, Tomonari A, Shimohakamada Y, Yamada T et al. Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with haematological malignancies. Blood 2004; 104: 3813–3820.

    Article  CAS  PubMed  Google Scholar 

  27. Sanz GF, Saavedra S, Planelles D, Senent L, Cervera J, Barragan E et al. Standardized, unrelated donor cord blood transplantation in adults with haematologic malignancies. Blood 2001; 98: 2332–2338.

    Article  CAS  PubMed  Google Scholar 

  28. Fernandez MN, Regidor C, Cabrera R, Garcia-Marco JA, Fores R, Sanjan I et al. Unrelated umbilical cord blood transplants in adults: early recovery of neutrophils by supportive co-transplantation of a low number of highly purified peripheral blood CD34+ cells from an HLA-haploidentical donor. Exp Haematol 2003; 31: 535–544.

    Article  Google Scholar 

  29. Goldman JM . Who will regulate the regulators. Bone Marrow Transplant 2004; 34: 1013–1014.

    Article  CAS  PubMed  Google Scholar 

  30. http://www.bristol-inquiry.org.uk/final_report/index.htm

Download references

Author information

Authors and Affiliations

  1. The Anthony Nolan Trust, Royal Free Hospital, London, UK

    R F Duarte, D Pamphilon, J Cornish, B E Shaw, D Samson, C Craddock, D Marks, G J Mufti, R L Powles, J F Apperley, J A Madrigal & J M Goldman

Authors
  1. R F Duarte
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D Pamphilon
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J Cornish
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B E Shaw
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D Samson
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C Craddock
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. D Marks
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. G J Mufti
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. R L Powles
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. J F Apperley
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. J A Madrigal
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. J M Goldman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to R F Duarte.

Appendix A. List of participants

Appendix A. List of participants

Jo Addada (Anthony Nolan Trust), Samia Al-Sarraj (Anthony Nolan Trust), Caroline Alvares (Royal Marsden Hospital, London), Jane Apperley (Imperial College London, Hammersmith Campus), Martín Barnado (Oxford Transplant Centre, Churchill Hospital), Finnuala Baker (Anthony Nolan Trust), Erik Bokmans (Amgen Limited, Cambridge Science Park), Linda Barber (Anthony Nolan Trust), Kay Bascombe (Anthony Nolan Trust), Joy Brennan (Royal Marsden Hospital, London), Fran Burke (Anthony Nolan Trust), Mark Caswell (Royal Liverpool Children's Hospital, Alder Hey), Richard Clark (Royal Liverpool University Hospital), Susan Cleaver (Anthony Nolan Trust), Jacqueline Cornish (Bristol Royal Hospital for Children), Steve Cox (Anthony Nolan Trust), Charles Craddock (The Queen Elisabeth Hospital, Birmingham), Anthony Dodi (Anthony Nolan Trust), Pauline Dodi (Anthony Nolan Trust), Rafael Duarte (Anthony Nolan Trust & King's College Hospital, London), Martin Ellis (Amgen Limited, Cambridge Science Park), Sandra Frater (Anthony Nolan Trust), Alex Frazier (Anthony Nolan Trust), Ian Galbraith (Glasgow Royal Infirmary), Mark Gibson (Anthony Nolan Trust), John Goldman (Anthony Nolan Trust), Ann Green (National Blood Service Bristol Centre), John Gribben (Barts and The London School of Medicine, London), Edel Harkin (Anthony Nolan Trust), Linda Hartwell (Anthony Nolan Trust), Darren Hatton (Anthony Nolan Trust), Richard Holman (Anthony Nolan Trust), Ann Hunter (Leicester Royal Infirmary), Sue Jordan (Anthony Nolan Trust), Majid Kazmi (Guy's and St Thomas’ Hospital, London), Michelle Keele (Anthony Nolan Trust), Marjorie Lawton (Anthony Nolan Trust), Effie Liakopoulou (Christie Hospital NHS Trust, Manchester), Zi Yi Lim (King's College Hospital, London), José A Limón (Imperial College London, Hammersmith Campus), Ann-Margaret Little (Anthony Nolan Trust), Tim Littlewood (The Osford Radcliffe Hospital), Stephen Mackinnon (Royal Free and University College Medical School, London), Alejandro Madrigal (Anthony Nolan Trust), David Marks (United Bristol Healthcare Trust), Stephen Marsh (Anthony Nolan Trust), Daniel McCloskey (Barts and The London School of Medicine), Katie Matthews (Anthony Nolan Trust), Neema Mayor (Anthony Nolan Trust), Stephen McEwan (Anthony Nolan Trust), Ghulam Mufti (King's College Hospital, London), Lucy Nicholls (United Bristol Healthcare Trust), Sandra Novack (Anthony Nolan Trust), Eduardo Olavarria (Imperial College London, Hammersmith Campus), Kim Orchard (Southampton General Hospital), Antonio Pagliuca (King's College Hospital, London), Derwood Pamphilon (Bristol Royal Hospital for Children), Anne Parker (Glasgow Royal Infirmary), Fotini Paterniou (Anthony Nolan Trust), (Anthony Nolan Trust), Andy Peniket (The Oxford Radcliffe Hospital), Jackie Penny (Amgen Limited, Cambridge Science Park), Mike Potter (Royal Marsden Hospital, London), Kay Poulton (Manchester Royal Infirmary), Ray Powles (Parkside Oncology Clinic, London), Chrissy Roberts (Anthony Nolan Trust), Nigel Russell (Nottingham City Hospital NHS Trust), Diane Samson (Imperial College London, Hammersmith Campus), Anila Shah (Anthony Nolan Trust), Anne Shurlock (Anthony Nolan Trust), Bronwen Shaw (Nottingham City Hospital NHS Trust), Rod Skinner (Royal Victoria Infirmary, Newcastle Upon Tyne), Mary Slatter (Newcastle General Hospital), David Tate (Manchester Royal Infirmary), Franco Tavarozzi (Anthony Nolan Trust), Caroline Thornton (Anthony Nolan Trust), Paul Travers (Anthony Nolan Trust), Paul Veys (Great Ormond Street Hospital, London), Robert Wynn (Royal Manchester Children's Hospital), John Yin (Manchester Royal Infirmary).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Duarte, R., Pamphilon, D., Cornish, J. et al. Topical issues in unrelated donor haematopoietic stem cell transplants: a report from a workshop convened by the Anthony Nolan Trust in London – 2005. Bone Marrow Transplant 37, 901–908 (2006). https://doi.org/10.1038/sj.bmt.1705365

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1705365

Keywords

Search

Advanced search

Quick links