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Post-Transplant Events

Risk and prognostic factors for Japanese patients with chronic graft-versus-host disease after bone marrow transplantation

Bone Marrow Transplantation volume 37, pages 289–296 (2006)Cite this article

A Corrigendum to this article was published on 04 October 2006

Abstract

The incidence and prognostic factors for chronic graft-versus-host disease (cGVHD) were evaluated for 255 Japanese patients who survived more than 100 days after bone marrow transplantation, and of whom 119 (47%) developed cGVHD. Prior acute GVHD (grade 2–4) and use of an unrelated donor were significantly associated with the onset of cGVHD. Presence of cGVHD did not have an impact on mortality (hazard ratio (HR)=0.89; 95% confidence interval (CI), 0.59–1.3). Three factors at diagnosis were associated with cGVHD-specific survival: presence of infection (HR=4.1; 95% CI, 1.6–10.3), continuing use of corticosteroids at the onset of cGVHD (HR=3.9; 95% CI, 1.7–9.1), and a Karnofsky performance score <80 (HR=4.7; 95% CI, 2.0–11.3). The probability of cGVHD-specific survival at 4 years was 79% (95% CI, 70–86%). The severity and death rate of Japanese patients with cGVHD was lower than those for populations in Western countries, which might be the result of greater genetic homogeneity of Japanese ethnics. Our patients could not be accurately classified when the proposed prognostic models from Western countries were used, thus indicating the need for a different model to identify high-risk patients.

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Acknowledgements

The authors are grateful for the assistance by and cooperation from all the staff members of the collaborating institutes of the Nagoya Blood and Marrow Transplantation Group.

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Authors and Affiliations

  1. Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, Japan

    Y Atsuta, K Yamamoto & N Hamajima

  2. Division of Molecular Medicine, Aichi Cancer Center, Nagoya, Japan

    R Suzuki

  3. Division of Hematology, Japan Red Cross Nagoya First Hospital, Nagoya, Japan

    S Terakura & Y Kodera

  4. Department of Hematology, Meitetsu Hospital, Nagoya, Japan

    H Iida & H Sao

  5. Division of Hematology and Oncology, JA Aichi Showa Hospital, Konan, Japan

    A Kohno & Y Morishita

  6. Department of Molecular Medicine and Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    K Yamamoto & T Naoe

  7. Division of Infectious Diseases, Hamamatsu Medical Center, Hamamatsu, Japan

    K Yano

  8. Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Hamamatsu, Japan

    A Wakita

  9. Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital, Nagoya, Japan

    H Taji & Y Morishima

  10. Clinical Research Center, Nagoya Medical Center, Nagoya, Japan

    M Hamaguchi

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  1. Y Atsuta
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  14. Y Morishima
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  15. N Hamajima
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  16. Y Morishita
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Correspondence to Y Atsuta.

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Atsuta, Y., Suzuki, R., Yamamoto, K. et al. Risk and prognostic factors for Japanese patients with chronic graft-versus-host disease after bone marrow transplantation. Bone Marrow Transplant 37, 289–296 (2006). https://doi.org/10.1038/sj.bmt.1705247

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  • DOI: https://doi.org/10.1038/sj.bmt.1705247

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