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Post-Transplant Events

Pre-transplant reduction of isohaemagglutinin titres by donor group plasma infusion does not reduce the incidence of pure red cell aplasia in major ABO-mismatched transplants

Bone Marrow Transplantation volume 36, pages 233–235 (2005)Cite this article

Summary:

Major ABO incompatibility in stem cell transplant recipients has been associated with pure red cell aplasia (PRCA). Reduction of incompatible isohaemagglutinin titres pre-transplant by various methods has been thought to reduce the incidence of PRCA. Our data suggest that pre-transplant reduction of incompatible isohaemagglutinin titres by donor group plasma infusion does not reduce the incidence of PRCA. We also failed to find any relationship between pre-transplant ABO isohaemagglutinin titre and the risk of developing PRCA.

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Authors and Affiliations

  1. Department of Hematology, Christian Medical College, Vellore, India

    S Damodar, B George, V Mathews, A Srivastava & M Chandy

  2. Department of Clinical Pathology and Blood Banking, Christian Medical College, Vellore, India

    J Mammen

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  1. S Damodar
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  2. B George
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  3. J Mammen
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  4. V Mathews
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  5. A Srivastava
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  6. M Chandy
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Correspondence to M Chandy.

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Damodar, S., George, B., Mammen, J. et al. Pre-transplant reduction of isohaemagglutinin titres by donor group plasma infusion does not reduce the incidence of pure red cell aplasia in major ABO-mismatched transplants. Bone Marrow Transplant 36, 233–235 (2005). https://doi.org/10.1038/sj.bmt.1705031

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