Summary:
We sought to assess if leaving in place a previously inserted noncolonized or infected implantable catheter (IC) is associated with an increase in morbidity in patients undergoing autologous peripheral stem cell transplantation (APSCT). Medical records from all patients between March 1997 and January 2002 undergoing APSCT with an IC in place were reviewed. Case group (IC in place) was compared with a control group (no IC) from 6 days prior to 60 days after APSCT. In all, 43 cases were matched with 43 controls by underlying disease, age and sex. In both groups, duration of neutropenia and use of antimicrobial prophylaxis were comparable. Underlying malignancies were lymphoma (22/24), multiple myeloma (14/12), leukemia (3/3), and others (7/7) in case and control groups. Cases and controls had comparable rates of risk for fever, bloodstream infection, use of vancomycin and amphotericin B, and death, as well as comparable lengths of stay and readmissions. ICs were used in 20 of 43 patients. Using the IC did not significantly increase the risk of fever, bloodstream infection, length of stay, and/or readmissions after APSCT but was associated with increased use of antibacterial and antifungal agents. Leaving in place a previously inserted, noncolonized or infected IC did not increase morbidity in patients undergoing APSCT.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gyves J, Ensminger W, Niederhuber J et al. Totally implanted system for intravenous chemotherapy in patients with cancer. Am J Med 1982; 73: 841–845.
Niederhuber JE, Ensminger W, Gyves JW et al. Totally implanted venous and arterial access system to replace external catheters in cancer treatment. Surgery 1982; 92: 706–712.
Biffi R, de Braud F, Orsi F et al. Totally implantable central venous access ports for long-term chemotherapy. A prospective study analyzing complications and costs of 333 devices with a minimum follow-up of 180 days. Ann Oncol 1998; 9: 767–773.
Chang L, Tsai JS, Huang SJ, Shih CC . Evaluation of infectious complications of the implantable venous access system in a general oncologic population. Am J Infect Control 2003; 31: 34–39.
Huang WT, Chen TY, Su WC et al. Implantable venous port-related infections in cancer patients. Support Care Cancer 2004; 12: 197–201.
Douard MC, Arlet G, Longuet P et al. Diagnosis of venous access port-related infections. Clin Infect Dis 1999; 29: 1197–1202.
Murray PR, Baron EJ . MAP Manual of Clinical Microbiology, 7th ed. American Society of Microbiology Press: Washington, DC, 1999.
Andremont A, Paulet R, Nitenberg G, Hill C . Value of semiquantitative cultures of blood drawn through catheter hubs for estimating the risk of catheter tip colonization in cancer patients. J Clin Microbiol 1988; 26: 2297–2299.
O'Grady NP, Alexander M, Dellinger EP et al. Guidelines for the prevention of intravascular catheter-related infections. Am J Infect Control 2002; 30: 476–489.
Linares J, Sitges-Serra A, Garau J et al. Pathogenesis of catheter sepsis: a prospective study with quantitative and semiquantitative cultures of catheter hub and segments. J Clin Microbiol 1985; 21: 357–360.
Brun-Buisson C, Abrouk F, Legrand P et al. Diagnosis of central venous catheter-related sepsis. Critical level of quantitative tip cultures. Arch Intern Med 1987; 147: 873–977.
Raad I, Costerton W, Sabharwal U et al. Ultrastructural analysis of indwelling vascular catheters: a quantitative relationship between luminal colonization and duration of placement. J Infect Dis 1993; 168: 400–407.
Carey PJ . Drug-induced myelosuppression: diagnosis and management. Drug Saf 2003; 26: 691–706.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Miceli, M., Dong, L., Coria, P. et al. Leaving previously implanted central venous catheters (ports) in place does not increase morbidity in patients undergoing autologous peripheral stem cell transplantation. Bone Marrow Transplant 36, 131–134 (2005). https://doi.org/10.1038/sj.bmt.1705018
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1705018