Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Candida krusei fungemia in an unrelated allogeneic hematopoietic stem cell transplant patient successfully treated with Caspofungin

Bone Marrow Transplantation volume 35, pages 1215–1216 (2005)Cite this article

Invasive fungal infections remain a major cause of morbidity and mortality, particularly in immunocompromised patients.1 The majority of fungal infections are caused by Candida or Aspergillus sp. Recently, the spectrum of fungal infections has significantly changed in favour of non-Candida albicans species, such as C. tropicalis, C. krusei, C. guillermondii, C. dubliniensis and C. glabrata.2 In addition, the emergence of azole resistance (mainly to fluconazole)3 and toxicity have resulted in the need for an expanded arsenal of antifungal drugs, such as Caspofungin.4

We report a patient with acute myeloid leukemia (AML) in CR, undergoing unrelated allogeneic hematopoietic stem cell transplant (HSCT), who developed a C. krusei fungemia, successfully treated with Caspofungin.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Segal BH, Bow EJ, Menichetti F . Fungal infections in nontransplant patients with hematologic malignancies. Infect Dis Clin North Am 2002; 16: 935–964.

    Article  Google Scholar 

  2. Krcmery V, Krupova I, Denning DW . Invasive yeast infections other than Candida spp. in acute leukaemia. J Hosp Infect 1999; 41: 181–194.

    Article  CAS  Google Scholar 

  3. Canuto MM, Rodero FG . Antifungal drug resistance to azoles and polyenes. Lancet Infect Dis 2002; 9: 550–563.

    Article  Google Scholar 

  4. Ullmann AJ . Review of the safety, tolerability and drug interactions of the new antifungal agents caspofungin and voriconazole. Curr Med Res Opin 2003; 19: 263–271.

    Article  CAS  Google Scholar 

  5. Onishi J, Meinz M, Thompson J et al. Discovery of novel antifungal 1,3-beta-D-glucan synthase inhibitors. Antimicrob Agents Chemother 2000; 44: 368–377.

    Article  CAS  Google Scholar 

  6. Bachman SP, Patterson TF, Lopez-Rilot JL . In vitro activity of caspofungin (MK –0991) against Candida albicans clinical isolates displaying different mechanisms of azole resistance. J Clin Microbiol 2002; 40: 2228–2230.

    Article  Google Scholar 

  7. McGee WT, Tereso GJ . Successful treatment of Candida krusei infection with caspofungin acetate, a new antifungal agent. Crit Care Med 2003; 31: 1577–1578.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Haematology and Bone Marrow Unit, Careggi Hospital and University of Florence, Italy

    R Fanci, S Guidi, M Bonolis & A Bosi

Authors
  1. R Fanci
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S Guidi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M Bonolis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A Bosi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fanci, R., Guidi, S., Bonolis, M. et al. Candida krusei fungemia in an unrelated allogeneic hematopoietic stem cell transplant patient successfully treated with Caspofungin. Bone Marrow Transplant 35, 1215–1216 (2005). https://doi.org/10.1038/sj.bmt.1704976

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1704976

Search

Advanced search

Quick links