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Post-Transplant Events

Long-term outcome of allogeneic or autologous haemopoietic cell transplantation for acute lymphoblastic leukaemia in second remission in children. GETMON experience 1983–1998

Bone Marrow Transplantation volume 35, pages 895–901 (2005)Cite this article

Summary:

We present a retrospective study of long-term outcome and predictive factors of survival and relapse in 219 paediatric patients with acute lymphoblastic leukaemia (ALL) in second remission. They received allogeneic (allo) or autologous (auto) haemopoietic cell transplantation (HCT) depending on the availability of a matched sibling donor. The probability of event-free survival (EFS) for the total patient group was 0.35+0.03 at 14 years. No significant differences were observed for EFS between allo- and auto-HCT: 0.39+0.05 vs 0.32+0.04 (P=0.43). A better EFS was seen in patients with a late relapse (LR) (P=0.06 and 0.02, for allogeneic and autologous respectively). Significantly better EFS was observed in allo-HCT patients under 10 years of age and in auto-HCT patients with leukocytes at diagnosis below 25 × 109/l and late relapse. Predictive factors of failure in both groups were early relapse (ER), medullary relapse and age over 10 years. The probability of relapse (RP) for the total group of patients was 0.57+0.03, and it was significantly higher in auto-HCT patients: 0.65+0.04 vs 0.42+0.06 (P=0.002). Factors predictive for relapse were medullary and early relapse, auto-HCT and WBC >25 × 109/l at diagnosis.

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Authors and Affiliations

  1. Hospital Sant Pau, Barcelona, Spain

    I Badell & J Cubells

  2. Hospital Ramón y Cajal-Universidad de Alcalá, Madrid, Spain

    A Muñoz & M Soledad-Maldonado

  3. Hospital Vall d'Hebrón, Barcelona, Spain

    J J Ortega & T Olivé

  4. Hospital La Paz, Madrid, Spain

    A Martínez & A Sastre

  5. Hospital Niño Jesús, Madrid, Spain

    L Madero, J Baro & M A Díaz

  6. Hospital Marqués de Valdecilla, Santander, Spain

    E Bureo

  7. Hospital La Fé, Valencia, Spain

    A Verdeguer

  8. Hospital Clínico, Valencia, Spain

    R Fernandez-Delgado

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for the Spanish Working Party for BMT in Children (GETMON)

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Correspondence to I Badell.

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Badell, I., Muñoz, A., Ortega, J. et al. Long-term outcome of allogeneic or autologous haemopoietic cell transplantation for acute lymphoblastic leukaemia in second remission in children. GETMON experience 1983–1998. Bone Marrow Transplant 35, 895–901 (2005). https://doi.org/10.1038/sj.bmt.1704932

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