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Allogeneic transplantation for hepatosplenic αβ T-cell lymphoma

Bone Marrow Transplantation volume 35, pages 931–934 (2005)Cite this article

Hepatosplenic T-cell lymphomas (HSTL) are a rare subgroup of peripheral T-cell lymphomas that usually express the γδ TCR.1 They have a distinct clinicopathological phenotype characterised by a young adult male preponderance, bone marrow involvement, hepatosplenomegaly without lymphadenopathy, thrombocytopenia and an aggressive course with poor prognosis. Cytogenetic studies frequently show an isochrome 7q, i(7)(q10) karyotype or trisomy 8, or both.2

Recently, it has been appreciated that a rarer αβ hepatosplenic subtype exists that shares most of the features of its γδ counterpart.3 The prognosis is dismal, with a median survival of approximately 9 months, despite a variety of chemotherapeutic approaches. Clearly, alternative treatment strategies are warranted for these young patients.

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Acknowledgements

None of the above authors has a conflict of interest in publication of this material. Dr Mansour, Morris and Peggs, and Professor Khwaja, MacKinnon and Linch were all directly involved in the care of this patient. The patient has read this case report and agreed to its publication.

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Authors and Affiliations

  1. Department of Haematology, Royal Free and University College Medical School, London, UK

    M R Mansour, E C Morris, A Khwaja, D C Linch, S Mackinnon & K S Peggs

  2. Department of Histopathology, Royal Free and University College Medical School, London, UK

    A Dogan

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  1. M R Mansour
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  7. K S Peggs
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Mansour, M., Dogan, A., Morris, E. et al. Allogeneic transplantation for hepatosplenic αβ T-cell lymphoma. Bone Marrow Transplant 35, 931–934 (2005). https://doi.org/10.1038/sj.bmt.1704897

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