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Red cell fragmentation preceding a renal crisis in a patient with systemic sclerosis undergoing haematopoietic stem cell transplantation

Bone Marrow Transplantation volume 35, pages 629–630 (2005)Cite this article

Systemic sclerosis (SSc) is an autoimmune condition characterized by the deposition of excess collagen in skin and internal organs. The pathogenesis of systemic sclerosis SSc is complex and incompletely understood; however, immune activation (T-cell activation and cytokine release) is thought to be an early factor, followed by tissue fibroblast activation and subsequent excess collagen deposition.1 A subset of patients with a high mortality rate can be identified on the basis of rapidly progressive disease, an elevated ESR, and renal or pulmonary disease.2 Although no proven effective treatment exists, several phase II trials suggest that high-dose immunosuppressive therapy with autologous stem cell rescue (HSCT) may be beneficial in arresting disease progression with improvement in skin and disease scores.3, 4, 5

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Authors and Affiliations

  1. Haematology Department, St Vincents Hospital, Sydney, Australia

    S David & J Moore

  2. Department of Rheumatology, Westmead Hospital, Westmead, Australia

    H Englert

  3. Department of Renal Medicine, St Vincents Hospital, Sydney, Australia

    T Furlong

  4. Department of Anatomical Pathology, St Vincents Hospital, Sydney, Australia

    S Rainer

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  1. S David
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  2. H Englert
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  4. S Rainer
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  5. J Moore
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David, S., Englert, H., Furlong, T. et al. Red cell fragmentation preceding a renal crisis in a patient with systemic sclerosis undergoing haematopoietic stem cell transplantation. Bone Marrow Transplant 35, 629–630 (2005). https://doi.org/10.1038/sj.bmt.1704832

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