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Lack of activity of allogeneic stem cell transplantation with reduced-intensity conditioning regimens in advanced sarcomas

Bone Marrow Transplantation volume 35, pages 421–422 (2005)Cite this article

The prognosis of advanced soft-tissue sarcomas (STS) and metastatic or high-risk localized small round cell tumor (SRCT) is dismal with a low proportion of patients surviving free of disease after conventional chemotherapy.1,2 Thus, novel approaches for the treatment of advanced sarcomas are needed.

From November 1999 to December 2002, nine patients with advanced sarcoma having an HLA-identical sibling were treated with a reduced-intensity conditioning regimen followed by allogeneic peripheral stem cell transplantation. Patients were treated with two reduced conditioning regimens: fludarabine 125 mg/m2 for 5 days plus cyclophosphamide 120 mg/kg for 2 days (FluCy1), and fludarabine 90 mg/m2 plus cyclophosphamide 900 mg/m2 for 3 days (FluCy2), based on clinical status at transplantation. One patient received melphalan 140 mg/m2 instead of cyclophosphamide on account of previous treatment.

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Authors and Affiliations

  1. Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Rozzano, Milan, Italy

    L Castagna, B Sarina, E Todisco, S Bramanti, A Bertuzzi, M Zuradelli & A Santoro

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  1. L Castagna
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  2. B Sarina
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  3. E Todisco
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  4. S Bramanti
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  5. A Bertuzzi
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  6. M Zuradelli
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  7. A Santoro
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Castagna, L., Sarina, B., Todisco, E. et al. Lack of activity of allogeneic stem cell transplantation with reduced-intensity conditioning regimens in advanced sarcomas. Bone Marrow Transplant 35, 421–422 (2005). https://doi.org/10.1038/sj.bmt.1704774

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