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Sinus bradycardia associated with cyclosporine following allogeneic hematopoietic stem cell transplantation

Bone Marrow Transplantation volume 35, pages 211–212 (2005)Cite this article

Arrhythmia following allogeneic hematopoietic stem-cell transplantation (allo-HSCT) can be seen in association with fluid overload, dimethyl sulfoxide (DMSO), and cyclophosphamide. Its cause remains unclear in most cases.

The clinical course of this patient demonstrates a dose-dependent association between sinus bradycardia and cyclosporine (Figure 1). These findings are consistent with the previous reports on solid organ transplantation, which documented cyclosporine-associated sinus bradycardia in 37 of 50 cases.1 Sinus bradycardia has not been documented in large phase III studies comparing cyclosporine with tacrolimus in allo-HSCT.2 The difference between solid organ transplantation and allo-HSCT might be attributable to the lower dosage of cyclosporine in allo-HSCT than that in organ transplant recipients.3

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Figure 1

References

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Authors and Affiliations

  1. Hematopoietic Stem Cell Transplantation Unit, the National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    G Fujisaki, M Kami, N Murashige, Y Kishi, C Inokuchi & R Tanosaki

  2. Division of Cardiology, Cardiovascular Center, Toranomon Hospital, Tokyo, Japan

    S Momomura

Authors
  1. G Fujisaki
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  2. M Kami
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  3. N Murashige
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  4. Y Kishi
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  5. C Inokuchi
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  6. R Tanosaki
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  7. S Momomura
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Fujisaki, G., Kami, M., Murashige, N. et al. Sinus bradycardia associated with cyclosporine following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 35, 211–212 (2005). https://doi.org/10.1038/sj.bmt.1704747

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