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Second cord blood transplantation (CBT) with reduced-intensity conditioning for graft failure after the first CBT for AML

Bone Marrow Transplantation volume 34, pages 999–1000 (2004)Cite this article

Graft failure is a life-threatening complication that occasionally occurs following hematopoietic stem cell transplantation (HSCT). The incidence of graft failure following allogeneic HSCT is below 5%.1 Risk factors include donor–recipient HLA or ABO mismatch, unrelated donor, less intense conditioning regimen, T-cell depletion, insufficient number of transplanted stem cells, and viral infections such as cytomegalovirus infection.1

Over the past several years, cord blood transplantation (CBT) has been increasingly performed for the treatment of adult hematological malignant diseases.2, 3, 4, 5 The advantages of CBT include prompt availability and less stringent requirement of HLA identity between donor and recipient because of the low risk of GVHD. However, CBT has been associated with delays in neutrophil and platelet recovery.5, 6 In previous studies, myeloid engraftment was achieved in 74–90% of adult patients who underwent CBT.4, 5 However, there are few data on the management of graft failure after CBT as CBT is a relatively new procedure.

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Acknowledgements

We thank Ms Megumi Ejiri for technical assistance and Ms Kimie Shibuya for secretarial assistance.

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  1. Department of Clinical Cell Biology, Chiba University, Graduate School of Medicine, 1-8-1, Inohana, Chuo-ku, Chiba City, 260-8670, Chiba, Japan

    C Ohwada, C Nakaseko, S Ozawa, M Takeuchi, K Shono, M Koizumi, E Sakaida, R Cho, Y Saito & M Nishimura

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  1. C Ohwada
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  2. C Nakaseko
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  3. S Ozawa
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Ohwada, C., Nakaseko, C., Ozawa, S. et al. Second cord blood transplantation (CBT) with reduced-intensity conditioning for graft failure after the first CBT for AML. Bone Marrow Transplant 34, 999–1000 (2004). https://doi.org/10.1038/sj.bmt.1704696

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