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Allografting

Does haploidentical transplantation in children with primary immunodeficiencies have the potential to exploit donor NK cell alloreactivity?

Bone Marrow Transplantation volume 34, pages 945–947 (2004)Cite this article

Summary:

Donor potential to exert NK cell alloreactivity has been shown to confer survival advantage in haploidentical hematopoietic cell transplantation for hematological malignancies. We investigated killer immunoglobulin receptor (KIR) ligand incompatibility in 40 children receiving haploidentical transplantation for primary immunodeficiencies. The conditioning regimen consisted of busulfan and cyclophosphamide. T-cell depletion of the graft used complement-dependent lysis or CD34+ selection. Two patients died in the first month. The remaining 38 patients were divided into those with (n=13) and those without (n=25) donor potential to exert NK cell alloreactivity. Engraftment was similar in the two groups (61.5 and 64%, respectively). The incidence of grade II–IV acute graft-versus-host disease (GVHD) tended to be lower in the group with donor potential to exert NK cell alloreactivity, but the difference was not significant. In conclusion, in this series of patients with primary immunodeficiencies, donor potential to exert NK cell alloreactivity was not associated with significant advantages in engraftment and prevention of acute GVHD.

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Acknowledgements

We are grateful to Andrea Velardi for a critical reading of the manuscript. We thank the excellent technical assistance of Edith Audran, Christine Deshayes, Nathalie Edy, and Patricia Przednowed. We are grateful to all patients and families, as well as to laboratory technicians and nurses. Clinical trial was supported by the ‘Direction à la Recherche Clinique de l'Assistance Publique-Hôpitaux de Paris’ and by ‘Agence Française contre les Myopathies’.

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Authors and Affiliations

  1. Department of Biotherapy, Hôpital Necker-Enfants Malades, Paris, France

    L Dal-Cortivo & M Cavazzana-Calvo

  2. Department of Pediatric Immuno-Hematology, Hôpital Necker-Enfants Malades, Paris, France

    M Ouachée-Chardin, I Hirsch, S Blanche, A Fischer & M Cavazzana-Calvo

  3. Laboratory of Immunology, Hôpital Necker-Enfants Malades, Paris, France

    S Caillat-Zucman

Authors
  1. L Dal-Cortivo
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  2. M Ouachée-Chardin
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  3. I Hirsch
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  4. S Blanche
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  5. A Fischer
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  6. M Cavazzana-Calvo
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  7. S Caillat-Zucman
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Correspondence to S Caillat-Zucman.

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Dal-Cortivo, L., Ouachée-Chardin, M., Hirsch, I. et al. Does haploidentical transplantation in children with primary immunodeficiencies have the potential to exploit donor NK cell alloreactivity?. Bone Marrow Transplant 34, 945–947 (2004). https://doi.org/10.1038/sj.bmt.1704663

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  • DOI: https://doi.org/10.1038/sj.bmt.1704663

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