Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Therapy-Related Myelodysplasia

Therapy-related myelodysplasia and leukemia occur infrequently following VP-16 priming and autotransplantation without total body irradiation

Bone Marrow Transplantation volume 34, pages 85–87 (2004)Cite this article

Summary:

The use of VP-16 for stem cell mobilization has been cited as a significant risk factor for the development of therapy-related myelodysplasia/leukemia (tMDS/tAML) following autologous transplantation. The present study analyzed a large cohort of patients who underwent autotransplantation following stem cell mobilization with VP-16 and radiation-free preparation in order to determine the risk of tMDS/tAML. The estimated incidence of 9.9% at 7 years suggests that in the absence of TBI, VP-16 priming is not associated with an increased incidence of tMDS/tAML.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Pedersen-Bjergaard J, Pedersen M, Myhre J, Geisler C . High risk of therapy-related leukemia after BEAM chemotherapy and autologous stem cell transplantation for previously treated lymphomas is mainly related to primary chemotherapy and not to the BEAM-transplantation procedure. Leukemia 1997; 11: 1654–1660.

    Article  CAS  Google Scholar 

  2. Darrington DL, Vose JM, Anderson JR et al. Incidence and characterization of secondary myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemoradiotherapy and autologous stem-cell transplantation for lymphoid malignancies. J Clin Oncol 1994; 12: 2527–2534.

    Article  CAS  Google Scholar 

  3. Stone RM, Neuberg D, Soiffer R et al. Myelodysplastic syndrome as a late complication following autologous bone marrow transplantation for non-Hodgkin's lymphoma. J Clin Oncol 1994; 12: 2535–2542.

    Article  CAS  Google Scholar 

  4. Miller JS, Arthur DC, Litz CE et al. Myelodysplastic syndrome after autologous bone marrow transplantation: an additional late complication of curative cancer therapy. Blood 1994; 83: 3780–3786.

    CAS  Google Scholar 

  5. Micallef IN, Lillington DM, Apostolidis J et al. Therapy-related myelodysplasia and secondary acute myelogenous leukemia after high-dose therapy with autologous hematopoietic progenitor-cell support for lymphoid malignancies. J Clin Oncol 2000; 18: 947–955.

    Article  CAS  Google Scholar 

  6. Armitage JO . Myelodysplasia and acute leukemia after autologous bone marrow transplantation (editorial). J Clin Oncol 2000; 18: 945–946.

    Article  CAS  Google Scholar 

  7. Ketterer N, Salles G, Dumontet C et al. Fludarabine may increase the toxicity of peripheral blood progenitor cell transplantation (abstract). Br J Haematol 1998; 102: 204.

    Google Scholar 

  8. Metayer C, Curtis RE, Vose J et al. Myelodysplastic syndrome and acute myeloid leukemia after autotransplantation for lymphoma; a multicenter case–control study. Blood 2003; 101: 2015–2022.

    Article  CAS  Google Scholar 

  9. Krishnan A, Bhatia S, Slovak ML et al. Predictors of therapy-related leukemia and myelodysplasia following autologous transplantation for lymphoma: an assessment of risk factors. Blood 2000; 95: 1588–1593.

    CAS  PubMed  Google Scholar 

  10. Copelan EA, Ceselski SK, Ezzone SA et al. Mobilization of peripheral blood progenitor cells with high dose etoposide and granulocyte colony-stimulating factor in patients with breast cancer, non-Hodgkin's lyphoma, and Hehmeyer Hodgkin's disease. J Clin Oncol 1997; 15: 759–765.

    Article  CAS  Google Scholar 

  11. Copelan EA, Penza SL, Pohlman B et al. Autotransplantation following busulfan, etoposide, and cyclophosphamide in patients with non-Hodgkin's lymphoma. Bone Marrow Transplant 2000; 25: 1219–1222.

    Article  CAS  Google Scholar 

  12. Thirman MJ, Larson RA . Therapy-related myeloid leukemia. In: Nimer SD, Golde DW (eds.). Hematology/Oncology Clinics of North America. Vol. 10. Saunders: Philadelphia, PA, 1996, pp 293–320.

    Google Scholar 

  13. Hosing C, Munsell M, Yazji S et al. Risk of therapy-related myelodysplastic syndrome and acute leukemia following high dose chemotherapy and autologous transplantation for non-Hodgkin's lymphomas (abstract). Blood 2000; 96: 401a.

    Google Scholar 

Download references

Acknowledgements

This work was supported in part by grant P30 CA16058, National Cancer Institute.

Author information

Authors and Affiliations

  1. Bone Marrow Transplantation Program, Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University Medical Center, Columbus, OH, USA

    E Copelan, P Elder, S Penza, S Farag, G Marcucci, T Lin, S Ezzone, M D Scholl & B Avalos

  2. Biostatistics Program, Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University Medical Center, Columbus, OH, USA

    S Hoshaw-Woodard & S Lemeshow

  3. Department of Pharmacy, Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University Medical Center, Columbus, OH, USA

    T Bechtel

Authors
  1. E Copelan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S Hoshaw-Woodard
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P Elder
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S Penza
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S Farag
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G Marcucci
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. T Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. S Ezzone
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. M D Scholl
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. T Bechtel
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. S Lemeshow
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. B Avalos
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E Copelan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Copelan, E., Hoshaw-Woodard, S., Elder, P. et al. Therapy-related myelodysplasia and leukemia occur infrequently following VP-16 priming and autotransplantation without total body irradiation. Bone Marrow Transplant 34, 85–87 (2004). https://doi.org/10.1038/sj.bmt.1704532

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1704532

Keywords

This article is cited by

Search

Advanced search

Quick links