Summary:
It is difficult to treat lung complications caused by chronic graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (allo-SCT). We retrospectively analyzed the characteristics of five patients with mediastinal emphysema (ME) and bilateral pneumothoraces (BP) caused by chronic lung GVHD after allo-SCT. Four of these patients had undergone unrelated SCT, and three had had HLA-identical unrelated donors. All patients received total body irradiation (TBI) during conditioning. Immunosuppressive agents were administered as GHVD prophylaxis, but two patients developed acute GVHD and all the five developed chronic GVHD. The onset of lung complications was 99–1915 days (median, 202 days) after SCT. The onset of ME and BP was 6–48 days (median, 23 days) after the onset of lung complications. Immunosuppressive agents were initially beneficial on the lung complications, but the patients later showed no response to therapy, and all died from respiratory failure 7–195 days (median, 28 days) after the development of ME and BP. The results suggest that these complications progress rapidly, are resistant to treatment, and have a poor prognosis. It is therefore important to start prophylaxis and treatment as early as possible.
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References
Clark JG, Hansen JA, Hertz MI et al. NHLBI workshop summary. Idiopathic pneumonia syndrome after bone marrow transplantation. Am Rev Respir Dis 1993; 147: 1601–1606.
Crawford SW, Hackman RC . Clinical course of idiopathic pneumonia after bone marrow transplantation. Am Rev Respir Dis 1993; 147: 1393–1400.
Weiner RS, Bortin MM, Gale RP et al. Interstitial pneumonitis after bone marrow transplantation. Assessment of risk factors. Ann Intern Med 1986; 104: 168–175.
Ettinger NA, Trulock EP . Pulmonary considerations of organ transplantation. Part 2. Am Rev Respir Dis 1991; 144: 213–223.
Krowka MJ, Rosenow III EC, Hoagland HC . Pulmonary complications of bone marrow transplantation. Chest 1985; 87: 237–246.
Neiman P, Wasserman PB, Wentworth BB et al. Interstitial pneumonia and cytomegalovirus infection as complications of human marrow transplantation. Transplantation 1973; 15: 478–485.
Beschorner W, Saral R, Hutchins G et al. Lymphocytic bronchitis associated with graft-versus-host disease in recipients of bone-marrow transplants. N Engl J Med 1978; 299: 1030–1036.
Holland HK, Wingard JR, Beschorner WE et al. Bronchiolitis obliterans in bone marrow transplantation and its relationship to chronic graft-v-host disease and low serum IgG. Blood 1988; 72: 621–627.
Roca J, Granena A, Rodriguez-Roisin R et al. Fetal airway disease in an adult with chronic graft-versus-host disease. Thorax 1982; 37: 77–78.
Thirman MJ, Devine SM, O'Toole K et al. Bronchiolitis obliterans organizing pneumonia as a complication of allogeneic bone marrow transplantation. Bone Marrow Transplant 1992; 10: 307–311.
Schwarer AP, Hughes JM, Trotman-Dickenson B et al. A chronic pulmonary syndrome associated with graft-versus-host-disease after allogeneic marrow transplantation. Transplantation 1992; 54: 1002–1008.
Yousem SA . The histological spectrum of pulmonary graft-versus-host disease in bone marrow transplant recipients. Hum Pathol 1995; 26: 668–675.
Yokoi T, Hirabayashi N, Ito M et al. Bronchiolitis obliterans as a complication of bone marrow transplantation: a clinicopathological study of eight autopsy cases. Virchows Arch 1997; 431: 275–282.
Kleinau I, Perez-Canto A, Schmid HJ et al. Bronchiolitis obliterans organizing pneumonia and chronic graft-versus-host disease in a child after allogeneic bone marrow transplantation. Bone Marrow Transplant 1997; 19: 841–844.
Palmas A, Tefferi A, Myers JL et al. Late-onset noninfectious pulmonary complications after allogeneic bone marrow transplantation. Br J Haematol 1998; 100: 680–687.
Johnson FL, Stokes DC, Ruggiero M et al. Chronic obstructive airways disease after bone marrow trasnplantation. J Pediatr 1984; 105: 370–376.
Hill G, Helenglass G, Powles R et al. Mediastinal emphysema in marrow transplant recipients. Bone Marrow Transplant 1987; 2: 315–320.
Hoshino Y, Hatake K, Mimuro J et al. Refractory bilateral pneumothoraces complicated with interstitial pneumonitis after bone marrow transplantation. Jpn J Clin Hematol 1993; 34: 718–722.
Toren A, Or R, Breuer R, Nagler A . Bronchiolitis obliterans presenting as subcutaneous emphysema and pneumomediastinum: a case report. Med Oncol 1996; 13: 195–197.
Matsumoto K, Yamaguchi T, Ichikawa M et al. Bronchiolitis obliterans in a patient with chronic graft-versus-host disease after bone marrow transplantation. Jpn J Thor Dis 1996; 34: 345–349.
Galanis E, Litzow MR, Tefferi A, Scott JP . Spontaneous pneumomediastinum in a patient with bronchiolitis obliterans after bone marrow transplantation. Bone Marrow Transplant 1997; 20: 695–696.
Suzuki T, Saijo Y, Ebina M et al. Bilateral pneumothraces with multiple bullae in a patient with asymptomatic bronchiolitis obliterans 10 years after bone marrow transplantation. Bone Marrow Transplant 1999; 23: 829–831.
Takahashi N, Maruta A, Hashimoto C et al. Idiopathic mediastinal and subcutaneous emphysema in a patient with acute lymphocytic leukemia after allogeneic bone marrow transplantation. Jpn J Clin Hematol 2000; 41: 1158–1163.
Kudoh T, Suzuki N, Oda T et al. Pneumomediastinum, subcutaneous emphysema, and pulmonary fibrosis in a patient with idiopathic pneumonia syndrome after bone marrow transplantation. Pediatr Hematol 2000; 17: 115–117.
Griese M, Rampf U, Hofmann D et al. Pulmonary complications after bone marrow transplantation in children: twenty-four years of experience in a single pediatric center. Pediatr Pulmonal 2000; 30: 393–401.
Kumar S, Tefferi A . Spontaneous pneumomediastinum and subcutaneous emphysema complicating bronchiolitis obliterans after allogeneic bone marrow transplantation-case report and review of literature. Ann Hematol 2001; 80: 430–435.
Perreault C, Cousineau S, D'Angero G et al. Lymphoid interstitial pneumonia after allogeneic bone marrow transplantation. A possible manifestation of chronic graft-versus-host disease. Cancer 1985; 55: 1–9.
Atkinson K, Bryant D, Delprado W, Biggs J . Widespread pulmonary fibrosis as a major clinical manifestation of chronic graft-versus-host disease. Bone Marrow Transplant 1989; 4: 129–132.
Afessa B, Litzow MR, Tefferi A . Bronchiolitis obliterans and other late oncet non-infectious pulmonary complications in hematopoietic stem cell transplantation. Bone Marrow Transplant 2001; 28: 425–434.
Ferrara JL, Deeg HJ . Graft-versus-host disease. N Engl J Med 1991; 324: 667–674.
Gale RP . Graft-versus-host disease. Immunol Rev 1985; 88: 193–214.
Meyers J, Flournoy N, Thomas ED . Nonbacterial pneumonia after allogeneic marrow transplantation: a review of ten years' experience. Rev Infect Dis 1982; 4: 1119–1132.
Sloane JP, DePledge MH, Powles RL et al. Histopathology of the lung after bone marrow transplantation. J Clin Pathol 1983; 36: 546–554.
Shulman HM, Sullivan KM, Weiden PL et al. Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients. Am J Med 1980; 69: 204–217.
Clark JG, Crawford SW, Madtes DK, Sullivan KM . Obstructive lung disease after allogeneic marrow transplantation. Clinical presentation and course. Ann Intern Med 1989; 111: 368–376.
Payne L, Chan CK, Fyles G et al. Cyclosporine as possible prophylaxis for obstructive airways disease after allogeneic bone marrow transplantation. Chest 1993; 104: 114–118.
Ikarashi Y, Abo T, Kawai K et al. Expansion of intermediate T-cell receptor cells of mice with autoimmune-like graft-versus-host-disease. Immunology 1994; 83: 205–212.
Cooke KR, Krenger W, Hill G et al. Host reactive donor T cells are associated with lung injury after experimental allogeneic bone marrow transplantation. Blood 1998; 92: 2571–2580.
Leskinen R, Taskinen E, Volin L et al. Use of bronchoalveolar lavage cytology and determination of protein contents in pulmonary complications of bone marrow transplant recipients. Bone Marrow Transplant 1990; 5: 241–245.
Quabeck K . The lung as a critical organ in marrow transplantation. Bone Marrow Transplant 1994; 14: S19–S28.
Lampert IA, Janossy G, Suitters AJ et al. Immunological analysis of the skin in graft versus host disease. Clin Exp Immnol 1982; 50: 123–131.
Favrot M, Janossy G, Tidman N et al. T cell regeneration after allogeneic bone marrow transplantation. Clin Exp Immunol 1983; 54: 59–72.
Cooke KR, Kobzik L, Martin TR et al. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: 1. The roles of minor H antigens and endotoxin. Blood 1996; 83: 3230–3239.
Nash RA, Antin JH, Karanes C et al. Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors. Blood 2000; 96: 2062–2068.
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Toubai, T., Tanaka, J., Kobayashi, N. et al. Mediastinal emphysema and bilateral pneumothoraces with chronic GVHD in patients after allogeneic stem cell transplantation. Bone Marrow Transplant 33, 1159–1163 (2004). https://doi.org/10.1038/sj.bmt.1704491
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DOI: https://doi.org/10.1038/sj.bmt.1704491
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