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Chromosomal transformation in donor cells following allogeneic bone marrow transplantation

Bone Marrow Transplantation volume 33, pages 1253–1256 (2004)Cite this article

Summary:

We report here a monosomy 7 transformation of donor cells following matched-unrelated, same sex, allogeneic bone marrow transplantation in a patient with severe congenital aplastic anemia. A PCR technique was employed to amplify microsatellite markers on chromosome 7 to confirm donor/recipient identity. We found that the transformation of monosomy 7 occurred in previously genetically normal donor cells. This study suggests that the microenvironment of the bone marrow of our patient with severe congenital aplastic anemia may have played a critical role in the development of monosomy 7 of normal donor cells and we conclude that chromosomal microsatellite marker analysis can be a valuable tool for precise donor/recipient differentiation in engraftment monitoring.

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Authors and Affiliations

  1. Center for Cancer and Blood Disorders, Washington, DC, USA

    Z Lang, P Dinndorf, S Ladisch, E Bayever & G Reaman

  2. Department of Hematology and Oncology, Children's National Medical Center, Washington, DC, USA

    Z Lang, P Dinndorf, S Ladisch, E Bayever & G Reaman

  3. Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA

    Z Lang, P Dinndorf, S Ladisch, E Bayever & G Reaman

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  1. Z Lang
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  2. P Dinndorf
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  3. S Ladisch
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  4. E Bayever
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  5. G Reaman
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Correspondence to G Reaman.

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Lang, Z., Dinndorf, P., Ladisch, S. et al. Chromosomal transformation in donor cells following allogeneic bone marrow transplantation. Bone Marrow Transplant 33, 1253–1256 (2004). https://doi.org/10.1038/sj.bmt.1704450

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