Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Contemporaneous appearance, 18 years after allogeneic bone marrow transplantation, of myelodysplastic syndrome in the patient and the donor

Bone Marrow Transplantation volume 33, pages 859–861 (2004)Cite this article

Summary:

We report the case of the development of two different stages of the same clonal disorder in two patients sharing the same bone marrow due to a previous bone marrow allotransplant. The transplanted patient developed severe aplasia with myeloid blasts, different from those of the previously cured leukemia. Chimerism evaluated by microsatellite analyses confirmed a full donor phenotype. At the same time, the donor of the bone marrow transplantation developed a refractory anemia with excess blasts. We speculate on the presence of an undetectable pre-existing pathological clone in the transplanted bone marrow, which have evolved in the two patients.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Steensma David P, Tefferi A . The myelodysplastic syndrome(s): a prospective and review highlight current controversies. Leukemia Res 2003; 27: 95–120.

    Article  CAS  Google Scholar 

  2. Mauritzson N, Albin M, Rylander L et al. Pooled analysis of clinical and cytogenetic features in treatment-related and de novo adult acute myeloid leukemia and myelodysplastic syndromes based on a consecutive series of 761 patients analyzed 1976–1993 and on 5098 unselected cases reported in the literature 1974–2001. Leukemia 2002; 16: 2366–2378.

    Article  CAS  Google Scholar 

  3. Han JY, Kim KH, Kwon HC et al. Unrelated clonal chromosome abnormalities in myelodysplastic syndromes and acute myeloid leukemias. Cancer Genet Cytogenet 2002; 132: 156–158.

    Article  CAS  Google Scholar 

  4. Heaney ML, Golde DW . Myelodysplasia. N Engl J Med 1999; 340: 1649–1660.

    Article  CAS  Google Scholar 

  5. Jan S, Ansamma J, German E et al. Immunity of patients surviving 20–30 years after allogeneic or syngeneic bone marrow transplantation. Blood 2001; 98: 3505–3512.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Oncology, Transplant and Advances in Medicine, Section of Hematology, University of Pisa, St Chiara Hospital, Pisa, Italy

    E Orciuolo, A Azzarà, S Galimberti, R Fazzi & M Petrini

  2. Institute of Hematology and Clinical Oncology ‘L e A Seragnoli’, University of Bologna, St Orsola Hospital, Bologna, Italy

    G Bandini & F Bonifazi

Authors
  1. E Orciuolo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Azzarà
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G Bandini
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S Galimberti
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F Bonifazi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R Fazzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M Petrini
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M Petrini.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Orciuolo, E., Azzarà, A., Bandini, G. et al. Contemporaneous appearance, 18 years after allogeneic bone marrow transplantation, of myelodysplastic syndrome in the patient and the donor. Bone Marrow Transplant 33, 859–861 (2004). https://doi.org/10.1038/sj.bmt.1704417

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1704417

Keywords

This article is cited by

Search

Advanced search

Quick links