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Contemporaneous appearance, 18 years after allogeneic bone marrow transplantation, of myelodysplastic syndrome in the patient and the donor

Bone Marrow Transplantation volume 33, pages 859–861 (2004)Cite this article

Summary:

We report the case of the development of two different stages of the same clonal disorder in two patients sharing the same bone marrow due to a previous bone marrow allotransplant. The transplanted patient developed severe aplasia with myeloid blasts, different from those of the previously cured leukemia. Chimerism evaluated by microsatellite analyses confirmed a full donor phenotype. At the same time, the donor of the bone marrow transplantation developed a refractory anemia with excess blasts. We speculate on the presence of an undetectable pre-existing pathological clone in the transplanted bone marrow, which have evolved in the two patients.

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Authors and Affiliations

  1. Department of Oncology, Transplant and Advances in Medicine, Section of Hematology, University of Pisa, St Chiara Hospital, Pisa, Italy

    E Orciuolo, A Azzarà, S Galimberti, R Fazzi & M Petrini

  2. Institute of Hematology and Clinical Oncology ‘L e A Seragnoli’, University of Bologna, St Orsola Hospital, Bologna, Italy

    G Bandini & F Bonifazi

Authors
  1. E Orciuolo
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  2. A Azzarà
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  3. G Bandini
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  4. S Galimberti
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  5. F Bonifazi
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  6. R Fazzi
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  7. M Petrini
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Corresponding author

Correspondence to M Petrini.

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Orciuolo, E., Azzarà, A., Bandini, G. et al. Contemporaneous appearance, 18 years after allogeneic bone marrow transplantation, of myelodysplastic syndrome in the patient and the donor. Bone Marrow Transplant 33, 859–861 (2004). https://doi.org/10.1038/sj.bmt.1704417

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  • DOI: https://doi.org/10.1038/sj.bmt.1704417

Keywords

  • MDS
  • acute leukemia

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