Summary:
Central venous catheters are frequently used in leukapheresis to provide high flow rates. The most common locations are the subclavian or jugular vein, but insertion-related complications and inadequate flow are frequent problems. Experience using femoral venous access is limited, because this has been discouraged due to the high incidence of infectious or thromboembolic complications. We evaluated the safety and efficacy of 108 short-term femoral venous dialysis catheters used for the collection of peripheral blood stem cells (PBSCs). All catheters were placed by a member of the dialysis unit, and they remained in situ for the days needed to reach the target number of CD34+cells. No prophylactic antibiotic or antithrombotic therapy was used. A total of 232 apheresis sessions was performed. The longest duration a catheter remained in situ was 5 days. Most of the patients finished the collection in one or two apheresis sessions. There were no thrombotic or infectious complications, and insertion-related complications or mechanical problems were minimal. Apheresis results were similar to those reported using subclavian or jugular venous access. The short-term use of femoral venous dialysis catheters appears safe and effective for PBSC collection, simplifying the procedure, improving patient comfort, and reducing cost.
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References
Smolowicz AC, Villman K, Tidefelt U . Large-volume apheresis for the harvest of peripheral blood progenitor cells for autologous transplantation. Transfusion 1997; 37: 188–192.
Thompson L . Central venous catheters for apheresis access. J Clin Apheresis 1992; 7: 154–157.
Johansson E, Hansson M, Sollén Nilsson A, Engervall P . Vascular access devices used during harvest of peripheral blood stem cells: high complication rate in patients with a long-term dialysis central catheter. Bone Marrow Transplant 1999; 24: 793–797.
Alegre A, Requena MJ, Fernández-Villalta M et al. Quinton–Mahurkar catheter as short-term central venous access for PBSC collection: single-centre experience or 370 apheresis in 110 patients. Bone Marrow Transplant 1996; 18: 865–869.
Hahn U et al. Large-bore central venous catheters for the collection of peripheral blood stem cells. J Clin Apheresis 1995; 10: 12–16.
Madero L et al. Non-tunnelled catheters for the collection and transplantation of peripheral blood stem cells in children. Bone Marrow Transplant 1997; 20: 53–56.
Bander SJ, Schwab J . Central venous angioaccess for hemodialysis and its complications. Semin Dial 1992; 5: 121–128.
Olivier MJ . Acute dialysis catheters. Semin Dial 2001; 14: 432–435.
Stenzel JP et al. Percutaneous femoral venous catheterization: a prospective study of complications. J Pediatr 1989; 114: 411–415.
Durbec O et al. A prospective evaluation of the use of femoral venous catheters in critically ill adults. Crit Care Med 1997; 25: 1986–1989.
Trottier S, Veremakis C, O'Brien J, Auer AI . Femoral deep vein thrombosis associated with central venous catheterization: results from a prospective, randomised trial. Crit Care Med 1995; 23: 52–59.
Merrer J, De Jonghe B, Golliot F et al. Complications of femoral and subclavian venous catheterization in critically ill patients. A randomised controlled trial. JAMA 2001; 286: 700–707.
Oliver MJ et al. Risk of bacteriemia from temporary hemodialysis catheters by site of insertion and duration of use: a prospective study. Kidney Int 2000; 58: 2543–2545.
Lazarus HM, Creger RJ, Bloom AD, Shenk R . Percutaneous placement of femoral central venous catheter in patients undergoing transplantation of bone marrow. Surg Gynecol Obstet 1990; 170: 403–406.
Shariatmadar S, Noto TA . Femoral vascular access for large-volume collection of peripheral blood progenitor cells. J Clin Apheresis 1998; 13: 99–102.
Adorno G, Zinno F, Bruno A et al. Femoral catheters: safety and efficacy in peripheral blood stem cell collection. Int J Artif Organs 1999; 22: 710–712.
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Moreiras-Plaza, M., Albo, C. & Ares, C. Efficacy and safety of femoral vascular access for peripheral blood stem cell (PBSC) collection. Bone Marrow Transplant 33, 347–350 (2004). https://doi.org/10.1038/sj.bmt.1704357
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DOI: https://doi.org/10.1038/sj.bmt.1704357