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Immune Reconstitution

Infused peripheral blood autograft absolute lymphocyte count correlates with day 15 absolute lymphocyte count and clinical outcome after autologous peripheral hematopoietic stem cell transplantation in non-Hodgkin's lymphoma

Bone Marrow Transplantation volume 33, pages 291–298 (2004)Cite this article

Summary:

Absolute lymphocyte count at day 15 (ALC-15) after autologous peripheral blood hematopoietic stem cell transplantation (APHSCT) is an independent prognostic factor for survival in non-Hodgkin's lymphoma (NHL). Factors affecting ALC-15 remain unknown. We hypothesized that dose of infused autograft lymphocytes (A-ALC) directly impacts upon ALC-15. A total of 190 consecutive NHL patients received A-ALC between 1993 and 2001. The primary end point was correlation between A-ALC and ALC-15. A strong correlation was identified (r=0.71). A higher A-ALC was infused into patients achieving an ALC-15 ⩾500/μl vs ALC-15 <500/μl (median of 0.68 × 109/kg (0.04–2.21 × 109/kg), vs 0.34 × 109/kg (0.04–1.42 × 109/kg), P<0.0001). The median follow-up for all patients was 36 months (maximum of 109 months). The A-ALC threshold was determined at 0.5 × 109/kg. The median overall survival (OS) and progression-free survival (PFS) times were longer in patients who received an A-ALC ⩾0.5 × 109/kg vs A-ALC <0.5 × 109/kg (76 vs 17 months, P<0.0001; 49 vs 10 months, P<0.0001, respectively). Multivariate analysis demonstrated A-ALC to be an independent prognostic indicator for OS and PFS. These data support our hypothesis that ALC-15 and survival are dependent upon the dose of infused A-ALC in NHL.

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Authors and Affiliations

  1. Division of Hematology, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA

    L F Porrata, M R Litzow, D J Inwards, D A Gastineau, S M Ansell, I N M Micallef & S N Markovic

  2. Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St, SW, Rochester, MN, 55905, USA

    D A Gastineau, S B Moore, A A Pineda, K L Bundy & D J Padley

  3. Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA

    D Persky

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  1. L F Porrata
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Correspondence to S N Markovic.

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Porrata, L., Litzow, M., Inwards, D. et al. Infused peripheral blood autograft absolute lymphocyte count correlates with day 15 absolute lymphocyte count and clinical outcome after autologous peripheral hematopoietic stem cell transplantation in non-Hodgkin's lymphoma. Bone Marrow Transplant 33, 291–298 (2004). https://doi.org/10.1038/sj.bmt.1704355

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