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Successful reduced-intensity stem cell transplantation (RIST) with mismatched cord blood in a 70-year-old patient with severe aplastic anemia (SAA)

Bone Marrow Transplantation volume 32, pages 1111–1112 (2003)Cite this article

Reduced-intensity stem cell transplantation (RIST) has been developed to reduce regimen-related toxicities (RRT) while preserving an adequate antitumor effect associated with allogeneic hematopoietic stem cell transplantation (allo-HSCT). RIST has been attempted in the treatment for various diseases.1 However, feasibility of RIST for severe aplastic anemia (SAA) remains to be established, because it has a high risk for graft rejection.2 With growing needs for alternative stem cell sources, use of cord blood (CB) as a stem cell resource can broaden the scope of patients who would benefit from allo-HSCT, but the data is limited.3,4 We will present a patient with SAA who had been successfully treated with RIST using CB.

A 70-year-old woman presented with petechiae and pancytopenia in June 2002. The complete blood count was white blood cell of 1.8 × 109/l, hemoglobin of 9.3 g/dl, and platelet of 18 × 109/l. Bone marrow biopsy disclosed fatty marrow with trilineage hypoplasia and normal karyotype, confirming a diagnosis of SAA. Her past medical history included rheumatoid arthritis (RA) with generalized joint deformities for 27 years, which had been treated with a variety of antirheumatic drugs including corticosteroids. Her RA had remained inactive with oral methylprednisolone 4 mg on every other day except for seasonal exacervation in winters.

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Authors and Affiliations

  1. Department of Hematology Toranomon Hospital, 2-2-2, Toranomon, Minato-ku, Tokyo, 105-8470, Japan

    E Kusumi, S Miyakoshi, K Yuji, J Ueyama, S Morinaga, S Taniguchi & Y Muto

  2. Hematopoietic Stem Cell Transplantation Unit, National Cancer Center Hospital, Tokyo, Japan

    N Murashige, Y Katayama, S-W Kim, M Kami & Y Takaue

  3. Department of Rheumatology and Hematology, The JR Tokyo General Hospital, Tokyo, Japan

    S Masuo

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  1. E Kusumi
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  2. S Miyakoshi
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  13. Y Muto
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Kusumi, E., Miyakoshi, S., Murashige, N. et al. Successful reduced-intensity stem cell transplantation (RIST) with mismatched cord blood in a 70-year-old patient with severe aplastic anemia (SAA). Bone Marrow Transplant 32, 1111–1112 (2003). https://doi.org/10.1038/sj.bmt.1704310

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