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Progenitor Cell Mobilisation

More efficient mobilisation of peripheral blood stem cells with HiDAC+AMSA+G-CSF than with mini-ICE+G-CSF in patients with AML

Bone Marrow Transplantation volume 32, pages 1119–1124 (2003)Cite this article

Summary:

We have compared the efficacy of two PBSC mobilisation regimens, mini-ICE+filgrastim (second consolidation) and HiDAC+AMSA+filgrastim (third consolidation), in two consecutive cohorts of patients with AML CR1 receiving treatment according to a joint protocol. Group A: 18 patients, aged 41 (21–65) years, were mobilised with mini-ICE (idarubicin 8 mg/m2+cytarabine 800 mg/m2+etoposide 150 mg/m2 days 1–3) followed by filgrastim 300–480 μg once daily s.c. from day 11 after start of chemotherapy. Only four patients reached >5 CD34+ cells/μl blood (B-CD34+) and were able to undergo leukaphereses. Two out of 18 (11%) reached the defined target of ⩾2.0 × 106 CD34+ cells/kg after 1–3 leukaphereses. Group B: 20 patients, aged 50 (29–67) years, received HiDAC+AMSA (cytarabine 3 g/m2 b.i.d. days 1, 3, 5+amsacrine 150 mg/m2 q.d. days 2, 4) followed by filgrastim at a similar dose starting on day 7. A total of 18 patients reached B-CD34+ >5/μl and underwent PBSC harvesting, starting on day 23 (14–29) and yielding 4.0 (0.9–21) × 106 CD34+ cells/kg. Of 20 patients, 17 (85%) reached the defined target of ⩾2.0 × 106 CD34+ cells/kg after 1–3 leukaphereses. We conclude that HiDAC+AMSA+G-CSF – in contrast to mini-ICE+G-CSF – is an efficient regimen for mobilising PBSC in patients with AML CR1.

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Authors and Affiliations

  1. Department of Hematology, University Hospital, Uppsala, Sweden

    M Höglund & B Simonsson

  2. Department of Hematology, University Hospital, Göteborg, Sweden

    M Brune & D Stockelberg

  3. Department of Hematology, University Hospital, Lund, Sweden

    B Sallerfors, R Billström & B Nilsson

  4. Department of Hematology, University Hospital, Malmö, Sweden

    T Ahlgren

  5. Department of Hematology, Central Hospital, Sundsvall, Sweden

    M Hedenus

  6. Department of Hematology, University Hospital, Umeå, Sweden

    B Markevärn & A Wahlin

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  1. M Höglund
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Correspondence to M Höglund.

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Höglund, M., Brune, M., Sallerfors, B. et al. More efficient mobilisation of peripheral blood stem cells with HiDAC+AMSA+G-CSF than with mini-ICE+G-CSF in patients with AML. Bone Marrow Transplant 32, 1119–1124 (2003). https://doi.org/10.1038/sj.bmt.1704294

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