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Inflammatory myofibroblastic tumor following hematopoietic stem cell transplantation: report of two pediatric cases

Bone Marrow Transplantation volume 33, pages 103–107 (2004)Cite this article

Summary:

Inflammatory myofibroblastic tumors are benign neoplasms histologically composed of lymphocytes, histiocytes, macrophages, foam cells, and plasma cells among a spindle-shaped stroma. Their etiology and potential for metastatic spread is controversial. Numerous predisposing factors have been suggested, including preceding infections, radiotherapy, and local trauma. We present two cases of pseudotumors that developed in children following hematopoietic stem cell transplantation. These are the first cases after hematopoietic transplant reported in the literature. As these neoplasms are difficult to diagnose and are often confused with highly aggressive tumors, our cases demonstrate that a high index of suspicion for such lesions must be maintained when evaluating masses in post transplant patients.

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Acknowledgements

We thank the families of JM and BC for their permission in the submission of this report. We thank Dr Brent Adler and Brad Hoehne for technical assistance.

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Authors and Affiliations

  1. The Center for Cancer Research, Columbus Children's Research Institute, The Ohio State University, Columbus, OH, USA

    J Fangusaro, K Klopfenstein & R A Altura

  2. Department of Pediatrics, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA

    J Fangusaro, K Klopfenstein & R A Altura

  3. Department of Surgery, Columbus Children's Hospital and College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA

    J Groner

  4. Department of Biopathology, Columbus Children's Hospital and College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA

    S Hammond

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  1. J Fangusaro
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  2. K Klopfenstein
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  3. J Groner
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  4. S Hammond
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  5. R A Altura
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Correspondence to R A Altura.

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Fangusaro, J., Klopfenstein, K., Groner, J. et al. Inflammatory myofibroblastic tumor following hematopoietic stem cell transplantation: report of two pediatric cases. Bone Marrow Transplant 33, 103–107 (2004). https://doi.org/10.1038/sj.bmt.1704292

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  • DOI: https://doi.org/10.1038/sj.bmt.1704292

Keywords

  • pseudotumor
  • inflammatory myofibroblastic tumor
  • children

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